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Related Experiment Video

Updated: Jan 10, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
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Biocompatibility Issues of Wound Dressings.

Elga I Alexander-Sinclair1, Ekaterina S Lapina1, Nikita V Edomenko1

  • 1Institute of Cytology of the Russian Academy of Sciences, 194064 St. Petersburg, Russia.

Bioengineering (Basel, Switzerland)
|November 27, 2025
PubMed
Summary

Eleven modern wound dressings (WDs) were evaluated for biocompatibility with human dermal fibroblasts. Parapran® demonstrated high biocompatibility and is suitable for use with bioengineered skin equivalents.

Keywords:
EDThe Dermal Equivalentbiocompatibilitybioengineered skin equivalentswound dressingswound healing

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Dermatology

Background:

  • Modern wound dressings (WDs) are crucial for acute and chronic wound management.
  • Bioengineered skin equivalents (BSEs) offer advanced wound healing solutions.
  • Understanding WD biocompatibility is essential for optimizing wound treatment strategies.

Purpose of the Study:

  • To assess the in vitro biocompatibility of 11 WDs with human dermal fibroblasts (DFs).
  • To evaluate the suitability of these WDs as secondary dressings for a hydrogel-based BSE, the Equivalent Dermal (ED).
  • To identify WDs that promote or inhibit fibroblast viability and function.

Main Methods:

  • In vitro biocompatibility testing using MTT assay on DFs.
  • Analysis of DF morphological state and actin cytoskeletal organization using WD extracts.
  • Evaluation of WD compatibility with the Equivalent Dermal (ED) BSE.

Main Results:

  • Significant variations in WD effects on DF viability and morphology were observed.
  • High biocompatibility was found for Parapran®, Lomatuell®H, Voskopran®, Metalline®, and Chitopran®.
  • Lower biocompatibility was noted for Granuflex®, Syspyr-derm®, HydroTac® transparent, Branolind®N, Aquacel™ adhesive foam, and Aquacel™Ag+.
  • Only Parapran® with chlorhexidine exhibited high biocompatibility with the ED BSE.

Conclusions:

  • WDs exhibit differential biocompatibility profiles, impacting their clinical application.
  • Parapran®, Lomatuell®H, Voskopran®, Metalline®, and Chitopran® are recommended for general wound treatment.
  • Granuflex®, Syspyr-derm®, HydroTac® transparent, Branolind®N, Aquacel™ adhesive foam, and Aquacel™Ag+ require cautious use.
  • Parapran® is the only suitable secondary dressing for the Equivalent Dermal BSE among the tested WDs.