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Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
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Covered Socket Residuum (CSR) in Former Third Molar Sockets Despite Platelet-Rich Fibrin: A Prospective Randomized
Shahram Ghanaati1, Atullo Kamalov1, Jerry Bouquot2
1FORM-Lab, Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of the Goethe University Frankfurt, Goethe University, 60590 Frankfurt am Main, Germany.
Bioengineering (Basel, Switzerland)
|November 27, 2025
Summary
Combining bone substitute materials with platelet-rich fibrin enhances bone regeneration after third molar extraction, leading to more mineralized bone formation and potentially reducing infection risks.
Area of Science:
- Oral surgery
- Regenerative medicine
- Biomaterials science
Background:
- Third molar extraction presents challenges in wound healing and bone regeneration.
- Bone substitute materials (BSMs) and platelet-rich fibrin (PRF) are utilized to aid socket healing.
- Optimizing regeneration strategies is crucial for successful post-extraction outcomes.
Purpose of the Study:
- To compare the efficacy of PRF combined with BSM versus PRF alone in supporting bone regeneration after third molar extraction.
- To evaluate the impact of these treatments on postoperative pain and swelling.
- To assess bone formation quality using cone beam computed tomography (CBCT).
Main Methods:
- Prospective randomized controlled split-mouth clinical trial involving 15 patients undergoing bilateral third molar extraction.
- Sockets were treated with either PRF alone (control) or BSM + PRF (test) under blinded conditions.
- Postoperative pain, swelling, and bone regeneration via CBCT were assessed over six months.
Main Results:
- No significant differences in postoperative pain or swelling were observed between the PRF alone and BSM + PRF groups.
- CBCT revealed non-mineralized areas (covered socket residuum) in the PRF only group.
- The BSM + PRF group showed more homogeneous and mineralized bone formation within extraction sites.
Conclusions:
- Combining BSM with PRF promotes superior bone regeneration compared to PRF alone after third molar extraction.
- This combination may mitigate risks associated with non-mineralized areas, such as infection.
- Further research is needed to identify the optimal BSM for this application.
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