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Updated: Jan 10, 2026
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Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
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Preserving Health Beyond Infection Control: Frailty, Weight, and Cognition in OPAT Patients.
Giacomo Ciusa1, Giuseppe Pipitone1, Bianca Catania1,2,3
1Infectious and Tropical Diseases Unit, A.R.N.A.S. Civico-Di Cristina-Benfratelli, 90100 Palermo, Italy.
Antibiotics (Basel, Switzerland)
|November 27, 2025
Summary
Outpatient Parenteral Antimicrobial Therapy (OPAT) is effective for complicated infections, maintaining patient weight, frailty, and cognitive status. This approach may prevent functional decline associated with hospitalization.
Area of Science:
- Infectious Diseases
- Geriatric Medicine
- Pharmacology
Background:
- Outpatient Parenteral Antimicrobial Therapy (OPAT) is a proven alternative to inpatient care for complex infections.
- Its impact on patient-centered outcomes like nutrition, frailty, and cognition is understudied.
- OPAT offers clinical efficacy, safety, and cost-effectiveness.
Purpose of the Study:
- To evaluate the impact of OPAT on patient-centered outcomes.
- To assess nutritional status, frailty, and cognitive well-being in patients receiving OPAT.
- To determine the clinical efficacy and safety of OPAT in a real-world setting.
Main Methods:
- A multicentric retrospective observational study was conducted.
- 119 patients treated with OPAT between April 2024 and July 2025 were analyzed.
- Data collected included demographics, comorbidities, weight, frailty (CFI), infection details, and follow-up assessments.
Main Results:
- 82.5% of patients achieved clinical recovery; 16% were readmitted within 30 days.
- Body weight and frailty index remained stable during OPAT.
- Cognitive status was unchanged in 85.6% of patients.
Conclusions:
- OPAT is clinically robust, well-tolerated, and may preserve weight, frailty, and cognitive function.
- OPAT could prevent hospitalization-related functional decline.
- Further prospective studies with standardized geriatric and cognitive assessments are warranted.
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