Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

228
Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
228
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

204
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
204

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Altered Brain Functional Connectivity in Postherpetic Neuralgia and Its Association With Neuropathic Pain.

Journal of clinical neurology (Seoul, Korea)·2026
Same author

Beneficial fungi reprogram tree metabolism toward growth and stress-associated pathways.

Applied and environmental microbiology·2026
Same author

Altered perivascular-aligned diffusivity in postherpetic neuralgia assessed by the DTI-ALPS index.

Frontiers in neuroscience·2026
Same author

Altered Structural Brain Connectivity in Postherpetic Neuralgia and its Association with Neuropathic Pain Severity: A Diffusion Tensor Imaging Study.

Brain topography·2026
Same author

Glymphatic System Dysfunction in Epilepsy: Clinical and Translational Perspectives.

Epilepsy currents·2026
Same author

Glymphatic dysfunction as a predictor of response to lacosamide add-on therapy in drug-resistant focal epilepsy.

Frontiers in neurology·2026

Related Experiment Video

Updated: Jan 10, 2026

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

23.0K

The Glymphatic System and Obesity: A Diffusion Tensor Imaging ALPS Study.

Kang Min Park1, Jin-Hong Wi2, Bong Soo Park3

  • 1Department of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Republic of Korea.

Biomedicines
|November 27, 2025
PubMed
Summary

Obesity is linked to reduced glymphatic system function, indicated by lower diffusion tensor image analysis along the perivascular space (DTI-ALPS) index, even in neurologically healthy adults. Maintaining a healthy weight is crucial for brain waste clearance and may prevent early neurodegeneration.

Keywords:
body mass indexglymphatic systemobesity

More Related Videos

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.6K
Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

12.6K

Related Experiment Videos

Last Updated: Jan 10, 2026

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

23.0K
Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
13:26

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography

Published on: August 11, 2016

12.6K
Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images
09:21

Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images

Published on: February 18, 2015

12.6K

Area of Science:

  • Neuroscience
  • Radiology
  • Public Health

Background:

  • Obesity is a known risk factor for neurodegenerative diseases.
  • Impaired glymphatic system function may underlie the link between obesity and brain dysfunction.
  • Glymphatic function in neurologically healthy obese individuals is not well understood.

Purpose of the Study:

  • To investigate glymphatic system function in neurologically healthy adults with varying obesity statuses.
  • To determine if the diffusion tensor image analysis along the perivascular space (DTI-ALPS) index differs between obese and non-obese individuals.

Main Methods:

  • Retrospective analysis of brain diffusion tensor imaging (DTI) data from 62 neurologically healthy participants.
  • Participants stratified into underweight, normal weight, overweight, and obese groups based on WHO Asia-Pacific BMI criteria.
  • Group differences in DTI-ALPS index examined using Mann-Whitney U tests and ANCOVA, adjusting for age.

Main Results:

  • Obese participants exhibited significantly lower DTI-ALPS index values compared to normal weight and overweight groups (p < 0.05).
  • Reduced DTI-ALPS index in obesity persisted after adjusting for age.
  • Obesity was associated with a significantly reduced DTI-ALPS index compared to the BMI < 25 kg/m² group (p = 0.015).

Conclusions:

  • This study provides the first evidence linking obesity to reduced glymphatic system function in neurologically healthy adults.
  • Lower DTI-ALPS index in obese individuals suggests impaired brain waste clearance.
  • Maintaining a healthy body weight is vital for preserving glymphatic function and potentially mitigating early neurodegenerative changes.