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Selectins

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
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Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
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Context-Dependent Roles of Siglec-F+ Neutrophils.

Kisung Sheen1, Taesoo Choi2, Man S Kim1,3

  • 1Translational-Transdisciplinary Research Center, Medical Science Research Institute, Kyung Hee University Hospital at Gangdong, Kyung Hee University College of Medicine, Seoul 05278, Republic of Korea.

Biomedicines
|November 27, 2025
PubMed
Summary

Siglec-F+ neutrophils are a unique immune cell type with long lifespans and diverse roles in infection, cancer, and fibrosis. Understanding their signaling and metabolism could lead to new immunomodulation therapies.

Keywords:
NETosisROSSiglec-8Siglec-Fanti-apoptosiseosinophillong-lived neutrophilneutrophil heterogeneity

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Neutrophils are key immune cells, but a distinct Siglec-F+ neutrophil population with unique properties has been identified.
  • These cells have extended lifespans and play varied roles in different disease contexts.

Purpose of the Study:

  • To review the differentiation and function of Siglec-F+ neutrophils.
  • To explore potential therapeutic strategies targeting these cells.

Main Methods:

  • Literature review of murine disease models and Siglec-F+ neutrophil research.
  • Analysis of Siglec-F signaling, metabolic programming, and cytokine influences.

Main Results:

  • Siglec-F+ neutrophils exhibit functional plasticity, impacting bacterial clearance, immune activation, immunosuppression, tumor progression, and tissue remodeling.
  • These cells differ from conventional neutrophils in their longevity and tissue residency.

Conclusions:

  • Siglec-F+ neutrophils represent a distinct and functionally versatile immune cell population.
  • Targeting Siglec-F signaling, metabolism, or cytokine regulation offers potential for precision immunomodulation in various diseases.