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Related Concept Videos

Inflammatory Response01:28

Inflammatory Response

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An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
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A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
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A Hot-Spring Water Improves Inflammatory Conditions in an Injury-Induced Atopic Dermatitis Mouse Model by Regulating

Yoko Naito1, Abdullah Md Sheikh1, Jubo Bhuiya2

  • 1Department of Laboratory Medicine, Faculty of Medicine, Shimane University, 89-1 Enya Cho, Izumo 693-8501, Japan.

Biomedicines
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Hot spring water aids skin barrier repair and reduces inflammation in atopic dermatitis (AD) models. This study shows it improves skin barrier function and mitigates inflammatory markers in AD.

Keywords:
CD8+ T cellsatopic dermatitisfilaggrinhot spring waterstratum spinosumtransepithelial water loss (TEWL)

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Area of Science:

  • Dermatology
  • Skin Biology
  • Immunology

Background:

  • Atopic dermatitis (AD) is a prevalent inflammatory skin condition.
  • Skin barrier dysfunction is a key factor in AD pathogenesis.
  • Hot spring water is recognized for its dermatological benefits.

Purpose of the Study:

  • To investigate the therapeutic effects of hot spring water on AD.
  • To evaluate its impact on skin barrier function and inflammation in an AD mouse model.

Main Methods:

  • An atopic dermatitis mouse model was induced using the tape-stripping method.
  • Mice were treated with either hot spring water or tap water.
  • Skin barrier function, histology, and AD-related protein levels were assessed over time.

Main Results:

  • Hot spring water treatment significantly reduced transepithelial water loss compared to tap water.
  • Histological analysis showed improved stratum spinosum and stratum granulosum in hot spring water-treated mice.
  • Filaggrin levels were higher, and CD8+ T cell counts and IL-4 levels were reduced, indicating reduced inflammation.

Conclusions:

  • Hot spring water effectively enhances skin barrier recovery in AD.
  • It demonstrates significant anti-inflammatory properties beneficial for managing AD.