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Updated: Jul 8, 2026
08:54
Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
Published on: April 27, 2015
17.3K
Liver Machine Perfusion: Past, Present and Future Directions.
Ivan Romic1,2, Davor Mijatovic1,2, Igor Petrovic1,2
1Department of Surgery, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.
Biomedicines
|November 27, 2025
Summary
Liver machine perfusion (LMP) is an innovative technique improving donor liver graft quality. Continuous research is vital to establish optimal guidelines for its clinical application in liver transplantation.
Area of Science:
- Hepatology
- Transplantation Surgery
- Organ Preservation
Background:
- Liver transplantation is the only cure for end-stage liver disease and some liver cancers.
- Donor organ shortage remains a critical barrier to reducing liver transplant waiting list mortality.
- Marginal and donation after cardiac death grafts are increasingly used, necessitating improved preservation methods.
Purpose of the Study:
- To review the development and evolution of liver machine perfusion (LMP).
- To analyze different LMP modalities and their operational mechanisms.
- To provide an overview of LMP's historical context, current use, and future potential.
Main Methods:
- Literature review of historical and recent studies on liver machine perfusion.
- Analysis of various LMP systems, including normothermic and hypothermic approaches.
- Examination of clinical outcomes and research trends in organ preservation.
Main Results:
- Liver machine perfusion has significantly advanced over the last decade.
- LMP is becoming a standard protocol in many transplant centers.
- Unresolved questions regarding LMP indications, types, and protocols necessitate further research.
Conclusions:
- Liver machine perfusion offers promising strategies to enhance the quality of donor liver grafts.
- Further research is essential to define optimal guidelines for clinical LMP application.
- LMP holds significant potential to improve outcomes in liver transplantation.
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