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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Transfusion01:15

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Hemodialysis I: Introduction01:25

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...

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Related Experiment Video

Updated: Jul 8, 2026

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
08:54

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

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Liver Machine Perfusion: Past, Present and Future Directions.

Ivan Romic1,2, Davor Mijatovic1,2, Igor Petrovic1,2

  • 1Department of Surgery, University Hospital Centre Zagreb, 10000 Zagreb, Croatia.

Biomedicines
|November 27, 2025
PubMed
Summary

Liver machine perfusion (LMP) is an innovative technique improving donor liver graft quality. Continuous research is vital to establish optimal guidelines for its clinical application in liver transplantation.

Keywords:
hypothermicliver machineperfusiontransplantation

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Related Experiment Videos

Last Updated: Jul 8, 2026

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion
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Area of Science:

  • Hepatology
  • Transplantation Surgery
  • Organ Preservation

Background:

  • Liver transplantation is the only cure for end-stage liver disease and some liver cancers.
  • Donor organ shortage remains a critical barrier to reducing liver transplant waiting list mortality.
  • Marginal and donation after cardiac death grafts are increasingly used, necessitating improved preservation methods.

Purpose of the Study:

  • To review the development and evolution of liver machine perfusion (LMP).
  • To analyze different LMP modalities and their operational mechanisms.
  • To provide an overview of LMP's historical context, current use, and future potential.

Main Methods:

  • Literature review of historical and recent studies on liver machine perfusion.
  • Analysis of various LMP systems, including normothermic and hypothermic approaches.
  • Examination of clinical outcomes and research trends in organ preservation.

Main Results:

  • Liver machine perfusion has significantly advanced over the last decade.
  • LMP is becoming a standard protocol in many transplant centers.
  • Unresolved questions regarding LMP indications, types, and protocols necessitate further research.

Conclusions:

  • Liver machine perfusion offers promising strategies to enhance the quality of donor liver grafts.
  • Further research is essential to define optimal guidelines for clinical LMP application.
  • LMP holds significant potential to improve outcomes in liver transplantation.