Related Experiment Video
Updated: Jan 10, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
Preventive and Therapeutic Interventions in Solar Elastosis and Photoaging: A Comprehensive Systematic Review
Francesco Leonforte1, Tiziano Pergolizzi2, Vito Nicosia3
1Department of Integrated Hygiene, Organizational, and Service Activities (Structural Department), Health Management, University Hospital Polyclinic "G. Rodolico-San Marco", 95123 Catania, Italy.
Combining energy-based devices with regenerative agents effectively treats solar elastosis and photoaging, improving skin structure and function. Further high-quality trials are needed to standardize protocols for these skin conditions.
Area of Science:
- Dermatology
- Photobiology
- Regenerative Medicine
Background:
- Solar elastosis is a key indicator of skin photodamage from UV exposure, causing wrinkles and laxity.
- Effective treatments are in demand due to the increasing prevalence of photoaging.
- This review synthesizes evidence on interventions for solar elastosis.
Purpose of the Study:
- To critically evaluate scientific evidence on interventions for solar elastosis.
- To provide an updated overview of therapeutic strategies.
- To guide future clinical practice for photoaging treatment.
Main Methods:
- Systematic review of PubMed, Scopus, ProQuest, and Web of Science (last 10 years).
- Inclusion of clinical studies on adults with solar elastosis and photoaging.
- Primary outcomes: clinical/histopathological improvement; Secondary outcomes: elasticity, safety, satisfaction.
Main Results:
- Twenty-two studies (608 participants) analyzed various therapies (lasers, stem cells, PRP).
- Combined device-assisted and regenerative treatments improved photoaging signs and elasticity.
- Treatments showed acceptable safety profiles with high patient satisfaction.
Conclusions:
- Combined energy-based devices and regenerative agents effectively improve photodamaged skin.
- Current literature has limitations: methodological heterogeneity and small sample sizes.
- High-quality RCTs with long-term follow-up are necessary for standardized protocols.
More Related Videos
Related Concept Videos
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Mutations
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Nucleotide Excision Repair
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Role of Skin in Vitamin D Synthesis
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...

