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  11. Maternal Dietary Choices Might Impact Intrauterine Healing Processes And Postnatal Phenotype And Function In Human Fetuses With Spina Bifida Aperta-early Clinical Observations And Implications From A Retrospective Cohort Study.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Maternal Dietary Choices Might Impact Intrauterine Healing Processes And Postnatal Phenotype And Function In Human Fetuses With Spina Bifida Aperta-early Clinical Observations And Implications From A Retrospective Cohort Study.

Related Experiment Video

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
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Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

712

Maternal Dietary Choices Might Impact Intrauterine Healing Processes and Postnatal Phenotype and Function in Human Fetuses with Spina Bifida Aperta-Early Clinical Observations and Implications from a Retrospective Cohort Study.

Thomas Kohl1

  • 1German Center for Fetal Surgery & Minimally-Invasive Therapy (DZFT), Mannheim University Hospital, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany.

Biomedicines
|November 27, 2025

View abstract on PubMed

Summary
This summary is machine-generated.
Keywords:
dietfetal surgeryfetoscopyfetus

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Maternal plant-based diets may improve healing and neurological outcomes for fetuses with spina bifida aperta (SBA). This suggests a potential non-invasive prenatal treatment to reduce secondary damage and improve postnatal recovery.

Area of Science:

  • Obstetrics and Gynecology
  • Pediatric Surgery
  • Fetal Medicine

Background:

  • Spina bifida aperta (SBA) severity is influenced by secondary damage to exposed neural tissue during gestation.
  • Prenatal interventions aim to mitigate these secondary factors.
  • This report explores a novel hypothesis for non-surgical prenatal secondary prophylaxis.

Purpose of the Study:

  • To present clinical cases of fetuses with SBA treated between 2010 and 2025.
  • To propose a new hypothesis for a nonsurgical means of prenatal secondary prophylaxis.
  • To investigate the potential impact of maternal diet on fetal outcomes in SBA.

Main Methods:

  • Eight fetuses with SBA underwent minimally invasive fetoscopic patch closure.
  • Postnatal outcomes, including skin closure time, were compared.
gastroschisis
meat
poultry
prophylaxis
spina bifida
vegan
vegetarian
  • Maternal dietary habits (plant-based, vegetarian, vegan) were recorded.
  • Two unoperated fetuses with SBA were also observed.

    • Main Results:

    • Fetuses undergoing prenatal patch closure showed significant prenatal healing.
    • Postnatal skin closure was faster in prenatally operated patients (22 days) compared to controls (44 days).
    • Mothers consuming plant-based diets reported better outcomes.

    Conclusions:

    • Maternal plant-based diets may ameliorate neurological deficits and enhance wound healing in fetal SBA.
    • This suggests a potential easily accessible, non-invasive secondary prophylaxis for SBA.
    • Further research is warranted to confirm the impact of maternal diet on fetal malformations.