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Kidney Transplant I: Introduction

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...

Kidney Structure

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.

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Updated: Jan 10, 2026

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

Efficient Vascularization of Kidney Organoids through Intracelomic Transplantation in Chicken Embryos

Published on: February 17, 2023

Kidney Organoids: Current Advances and Applications.

Hiroyuki Nakanoh¹, Kenji Tsuji¹, Kazuhiko Fukushima¹

¹Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.

Life (Basel, Switzerland)

|November 27, 2025

Summary

This summary is machine-generated.

Kidney organoids derived from stem cells are advanced 3D models for studying kidney development and disease. Future innovations aim to improve their maturity and clinical applications in nephrology.

Keywords:

disease modeling drug screening drug toxicity kidney organoid regenerative medicine stem cell

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Generation of Human Kidney Tubuloids from Tissue and Urine

Generation of Human Kidney Tubuloids from Tissue and Urine

Published on: April 16, 2021

Area of Science:

Biomedical Engineering
Stem Cell Biology
Nephrology

Background:

Kidney organoids are 3D in vitro models derived from stem cells.
They mimic key aspects of kidney development, structure, and function.
Advances enable generation of organoids with nephron-like structures (glomerular and tubular).

Purpose of the Study:

Highlight recent advances in kidney organoid research.
Outline major applications of kidney organoids.
Discuss future directions for enhancing physiological relevance and translational integration.

Main Methods:

Utilizes stem cell differentiation protocols.
Incorporates tissue engineering techniques.
Leverages microfluidics and bioengineering for refinement.

Main Results:

Kidney organoids serve as models for disease, drug screening, and regenerative medicine.
Patient-specific modeling is enabled for genetic kidney diseases like PKD and CAKUT.
Current limitations include incomplete maturation and variability.

Conclusions:

Kidney organoids show promise for studying genetic kidney diseases and evaluating drug nephrotoxicity.
Technological innovations are expected to refine kidney organoid systems.
Further development is needed to enhance functional maturity and clinical translation in nephrology.