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Serotonin Signaling Pathway Modulation Affects Retinal Neuron Survival in Experimental Model of Retinal Ischemia
Joanna Machowicz1,2, Klaudia Mróz1, Anna Pacwa1,3,4
1The Laboratory of Translational Research in Ophthalmology, Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.
Life (Basel, Switzerland)
|November 27, 2025
Summary
Selective serotonin reuptake inhibitors (SSRIs) like Escitalopram protect retinal neurons from ischemic injury. This study shows Escitalopram treatment preserves retinal ganglion cells and improves visual function in rats.
Area of Science:
- Neuroscience
- Ophthalmology
- Pharmacology
Background:
- Serotonin is crucial for visual processing, and SSRIs enhance its effects.
- Neuroprotective roles of SSRIs are known in the central nervous system, but not in the retina.
- The effect of Escitalopram on retinal neurons post-ischemic injury requires investigation.
Purpose of the Study:
- To determine if Escitalopram offers neuroprotection to retinal neurons against ischemic damage.
- To assess the impact of Escitalopram on retinal structure and function after induced ischemia.
Main Methods:
- Rats were treated with Escitalopram or vehicle for 12 weeks before retinal ischemia induction via episcleral vein cauterization.
- Retinal function was evaluated using electroretinography (ERG), and intraocular pressure (IOP) was monitored.
- Retinal tissue was analyzed using immunofluorescence and Western blot to assess cell survival and neurotrophic factor expression.
Main Results:
- Escitalopram treatment alleviated the reduction in retinal ganglion cells caused by ischemia.
- Escitalopram increased the expression of brain-derived neurotrophic factor (BDNF).
- Electroretinography showed improved photopic negative response (PhNR) amplitudes in Escitalopram-treated rats, indicating preserved retinal ganglion cell function.
Conclusions:
- Escitalopram demonstrates significant neuroprotective effects against retinal ischemic injury in rats.
- The findings suggest Escitalopram reduces both functional and structural retinal damage.
- Escitalopram may be a promising therapeutic agent for retinal neurodegenerative diseases.
