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Prognostic Value of Fibrinogen-to-Albumin Ratio and Neutrophil-to-Lymphocyte Ratio in Patients on Peritoneal Dialysis

Selena Gajić1, Ana Bontić1,2, Aleksandar Sič2

  • 1Clinic of Nephrology, University Clinical Center of Serbia, Pasterova 2, 11000 Belgrade, Serbia.

Life (Basel, Switzerland)
|November 27, 2025
PubMed

Insights

The fibrinogen-to-albumin ratio (FAR) significantly predicts adverse outcomes and mortality in peritoneal dialysis (PD) patients. The neutrophil-to-lymphocyte ratio (NLR) showed limited prognostic value, suggesting FAR may aid in risk stratification.

Area of Science:

  • Nephrology
  • Clinical Chemistry
  • Inflammation Research

Background:

  • Chronic inflammation is prevalent in peritoneal dialysis (PD) patients, impacting outcomes.
  • The prognostic utility of neutrophil-to-lymphocyte ratio (NLR) and fibrinogen-to-albumin ratio (FAR) in PD is not well-established.

Purpose of the Study:

  • To evaluate the prognostic value of inflammatory markers, specifically NLR and FAR, in PD patients.
  • To identify predictors of adverse outcomes, including mortality and transfer to hemodialysis (HD).

Main Methods:

  • Prospective cohort study of 65 PD patients followed for 18 months.
  • Collection of baseline demographic, clinical, and laboratory data.
  • Calculation of inflammatory indices and logistic regression analysis for outcome prediction.

Main Results:

  • Higher baseline FAR, C-reactive protein (CRP), and parathyroid hormone (PTH) were independently associated with adverse outcomes.
  • FAR was a significant predictor of both composite adverse outcomes and mortality.
  • NLR demonstrated only marginal significance in predicting adverse outcomes.

Conclusions:

  • FAR is a significant prognostic marker for adverse outcomes and mortality in PD patients.
  • FAR may serve as a valuable tool for risk stratification, complementing existing markers.
  • Further multicenter studies are recommended to validate these findings.
Abstract

Keywords:
chronic inflammationfibrinogen-to-albumin ratioinflammatory markersmortalityneutrophil-to-lymphocyte ratioperitoneal dialysis

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