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Updated: Jan 10, 2026

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
Published on: May 5, 2023
Periostin-Induced Wnt10a Activation Promotes Dental Pulp Stem Cell Migration During Pulp Regeneration.
Keisuke Nakamura1, Natsuki Iida1, Yuki Hayashi1
1Department of Pediatric Dentistry, School of Dentistry, Aichi Gakuin University, 2-11 Suemori-dori, Chikusa-ku, Nagoya 464-8651, Aichi, Japan.
Periostin enhances dental pulp stem cell (DPSC) migration by increasing Wnt10a expression and suppressing DKK1. This highlights Periostin
Area of Science:
- Dental Pulp Regeneration
- Stem Cell Biology
- Wnt Signaling Pathway
Background:
- Periostin is recognized as a Wnt signaling pathway stimulator.
- Understanding the Wnt10a and Periostin interaction in dental pulp stem cells (DPSCs) is crucial for regenerative mechanisms.
Purpose of the Study:
- To investigate the relationship between Periostin and Wnt10a in DPSCs.
- To elucidate the role of Periostin in DPSC migration and proliferation.
Main Methods:
- Analyzing Wnt10a and Periostin expression in regenerated dental pulp tissue via PCR.
- Assessing Wnt10a and DKK1 levels in Periostin-stimulated DPSCs.
- Evaluating protein expression using Western blotting and ELISA.
Main Results:
- Migrating DPSCs expressed Wnt10a, with migration inhibited by DKK1.
- Periostin stimulation led to increased Wnt10a secretion and decreased DKK1 expression.
- Periostin significantly promoted DPSC migration and Wnt10a expression.
Conclusions:
- Periostin acts as a positive regulator of Wnt10a expression and DPSC migration.
- DKK1 antagonizes the effects of Periostin on Wnt10a expression and DPSC migration.
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