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Zebrafish as an Integrative Model for Central Nervous System Research: Current Advances and Translational
Lidia Pansera1,2, Kamel Mhalhel1,2, Mauro Cavallaro2
1Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno D'Alcontres 31, 98166 Messina, Italy.
Life (Basel, Switzerland)
|November 27, 2025
Summary
Zebrafish models offer a powerful tool for studying central nervous system (CNS) disorders. Their genetic and anatomical similarities to humans aid in understanding disease and developing new therapeutics.
Area of Science:
- Neuroscience
- Genetics
- Pharmacology
Background:
- Central nervous system (CNS) disorders are diverse and impact global public health.
- Many CNS conditions are poorly understood, necessitating advanced research models.
- Developing effective therapeutic strategies requires better insight into disease pathophysiology.
Purpose of the Study:
- To review the current state of zebrafish models for CNS disorders.
- To highlight the potential of zebrafish in understanding disease mechanisms.
- To showcase their utility in screening novel therapeutics.
Main Methods:
- Review of existing literature on zebrafish models for CNS disorders.
- Analysis of zebrafish genetic and neuroanatomical homology with humans.
- Evaluation of zebrafish CNS regenerative capabilities.
Main Results:
- Zebrafish exhibit significant genetic and neuroanatomical homology with humans.
- Conservation of cellular architecture and blood-brain barrier in zebrafish.
- Remarkable regenerative capacity of the zebrafish central nervous system.
Conclusions:
- Zebrafish are a valuable model organism for CNS disorder research.
- These models facilitate the comprehension of pathophysiological processes.
- Zebrafish models show promise for therapeutic screening and development.
