Intraoperative Platelet-Rich Plasma Application Improves Scar Healing After Cesarean Section: A Prospective...

Area of Science:

• Regenerative Medicine
• Obstetric Surgery
• Wound Healing Research

Background:

• Cesarean delivery frequently results in scarring, impacting patient recovery.
• Platelet-rich plasma (PRP) contains growth factors beneficial for tissue regeneration.
• The effectiveness of PRP for cesarean scar healing is not well-established.

Purpose of the Study:

• To evaluate the efficacy of intraoperative Platelet-rich plasma (PRP) in improving cesarean delivery scar healing.
• To assess the impact of PRP on postoperative inflammation and hematological recovery.
• To explore correlations between hematological parameters and scar assessment scores.

Main Methods:

• A single-arm prospective observational study involving 50 cesarean section patients.
• Intraoperative PRP application in two stages: before hysterorrhaphy and before skin closure.
• Scar assessment using six validated scales at 7 and 40 days post-surgery.
• Monitoring of hematological parameters (hemoglobin, hematocrit, leukocyte, platelet counts).

Main Results:

• Significant improvement in mean scar scores from day 7 to day 40 (p < 0.001).
• Observed improvements in hematological parameters between day 7 and day 40.
• Exploratory correlations found between hemoglobin, leukocyte, and platelet counts with scar assessment scales.

Conclusions:

• Intraoperative PRP administration significantly enhances postoperative scar healing after cesarean delivery.
• PRP treatment was associated with reduced inflammation and improved hematological recovery.
• Further randomized controlled trials are needed to confirm PRP efficacy and long-term outcomes.