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Regression Toward the Mean01:52

Regression Toward the Mean

Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when researchers try to extrapolate results...

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Movement-Based Mindfulness vs. Attention Control for Modifying Physiological Risk in Chronic Stroke: Evidence from a

Tharshanah Thayabaranathan1,2,3, Marina Paul4,5,6, Frederick R Walker4,5,6

  • 1School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC 3168, Australia.

Healthcare (Basel, Switzerland)
|November 27, 2025
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Summary

Mindfulness-based interventions (MBI) show promise in managing post-stroke cardiovascular risk factors. This study found clinically meaningful improvements in blood pressure and lipid profiles in stroke survivors receiving an MBI.

Keywords:
biomarkersblood pressurefeasibility trialmindfulnessrisk factorsstroke

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Area of Science:

  • Neurology
  • Cardiovascular Health
  • Psychology

Background:

  • Managing physiological risk factors post-stroke is crucial but difficult.
  • Stroke survivors often face challenges with blood pressure, lipids, stress, and blood glucose.
  • Mindfulness-based interventions (MBI) offer a potential avenue for managing these factors.

Purpose of the Study:

  • To examine changes in physiological risk factors after a stroke-tailored mindfulness-based intervention (MBI) compared to an attention control.
  • To assess the feasibility and preliminary efficacy of an MBI in post-stroke cardiovascular risk management.
  • To evaluate effects on blood pressure, stress markers, HbA1c, and lipid profiles.

Main Methods:

  • A sub-study of a randomized controlled trial involving 38 participants (3-18 months post-stroke).
  • Participants were randomized to a 12-week MBI (yoga and meditation) or an attention control group.
  • Outcomes included blood pressure, perceived stress, hair cortisol, HbA1c, and lipid profiles.

Main Results:

  • The MBI group demonstrated clinically meaningful within-group reductions in systolic (5 mmHg) and diastolic (4 mmHg) blood pressure.
  • Exploratory analysis indicated favorable trends in HDL and LDL lipid profiles within the MBI group.
  • Positive trends were observed in stress markers, including hair cortisol (d = 0.52), within the MBI group.

Conclusions:

  • This feasibility trial suggests MBIs may help manage cardiovascular risk factors in post-stroke individuals.
  • Preliminary findings indicate clinically meaningful improvements in blood pressure and lipid profiles.
  • Larger trials are warranted to confirm the efficacy of MBIs for post-stroke cardiovascular risk management.