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Updated: Jan 10, 2026
![Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F2755.jpg&w=3840&q=50)
Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB
Published on: June 28, 2011
Co(II)-Catalyzed Picolinamide-Directed C(sp3)-S Bond Formation with N-(phenylsulfanyl)succinimides
Jinjing Qin1,2, Shaodong Zhou1, Jinwen Luo2
1College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, China.
None:
Herein, we disclose a novel and efficient cobalt-catalyzed cross-coupling strategy for picolinamide-directed direct C(sp3)-H bond formation with N-(phenylsulfanyl)succinimides. This method enables the direct construction of C(sp3)-S bonds under mild conditions and exhibits excellent functional group tolerance along with a broad substrate scope. Notably, the catalytic system achieves oxidative C-H functionalization without relying on costly or environmentally detrimental oxidants, offering a more sustainable and practical alternative for C-S bond formation.
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