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Updated: Jan 10, 2026

Preparation of Contiguous Bisaziridines for Regioselective Ring-Opening Reactions
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Conformational Evolution of Bicalutamide in Chloroform: A Comprehensive NMR Study.

Konstantin V Belov1, Ilya A Khodov1,2

  • 1G.A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences, Ivanovo 153045, Russia.

Molecules (Basel, Switzerland)
|November 27, 2025
PubMed
Summary

Researchers studied bicalutamide conformation using NOE NMR. Findings reveal that molecules transition to a «closed» conformation at low concentrations, influencing nucleation and solid-phase formation.

Keywords:
2D NOESYbicalutamideconformational polymorphismnon-steroidal antiandrogensolid phase

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