Related Experiment Video
Updated: Jan 10, 2026

Engineering Chimeric Antigen Receptor-Natural Killer Cells Targeting Fungal Infections Using the Non-viral Sleeping Beauty Transposon System
Published on: October 4, 2024
Cytotoxic Cytochalasans from Sponge-Derived Aspergillus sp. SCSIO 41044
Xiaoyan Pang1,2, Ini Wong3, Qinlin Cao1,4
1State Key Laboratory of Tropical Oceanography/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.
Abstract:
Two new cytochalasans (1-2), along with eight known ones (3-10) were isolated from sponge-derived Aspergillus sp. SCSIO 41044. The planar structures of 1-2 were elucidated through extensive spectroscopic analyses and their absolute configurations determined by modified Mosher's methods. Biological evaluation revealed that 5, 7, and 8 showed potent cytotoxicity against small cell lung cancers H446 and H1048, with IC50 values ranging from 0.0441 to 1.61 μM.

