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Post-Traumatic Stress Disorder (PTSD) and Cardiovascular Diseases: A Systematic Review and Meta-Analysis

Omar Anwar Saleh Al Nakhebi1, Raluka Albu-Kalinovic1, Oana Neda-Stepan1

  • 1Doctoral School, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Journal of Clinical Medicine
|November 27, 2025
PubMed

Insights

This study found a significant two-way link between cardiovascular disease (CVD) and post-traumatic stress disorder (PTSD). Integrating trauma care into heart health and stress management into PTSD treatment is crucial.

Area of Science:

  • Cardiology
  • Psychiatry
  • Public Health

Background:

  • Post-traumatic stress disorder (PTSD) is a significant mental health condition.
  • Cardiovascular disease (CVD) remains a leading cause of mortality worldwide.
  • The interplay between PTSD and CVD requires further investigation.

Purpose of the Study:

  • To conduct a meta-analysis examining the bidirectional association between PTSD and CVD.
  • To assess the risk of CVD incidence in individuals with PTSD.
  • To determine the prevalence of PTSD in patients diagnosed with CVD.

Main Methods:

  • Systematic literature search adhering to PRISMA guidelines.
  • Inclusion of 18 studies for PTSD-to-CVD risk analysis.
  • Inclusion of 11 studies for CVD-to-PTSD prevalence analysis.

Main Results:

  • Confirmed a bidirectional and clinically significant relationship between PTSD and CVD.
  • Evidence supports increased CVD incidence in individuals with PTSD.
  • Significant prevalence of PTSD observed in patients with CVD.

Conclusions:

  • The findings highlight a critical link between mental health and cardiovascular health.
  • Integrating trauma-informed care into cardiovascular services is recommended.
  • Incorporating stress management into psychiatric care for PTSD patients is essential to break the cycle.

Keywords:
Post-Traumatic Stress Disorder (PTSD)cardiovascular diseases

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