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Related Experiment Video

Updated: Jan 10, 2026

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Redo-Transcatheter Aortic Valve Implantation (Redo-TAVI)-Pilot Study from Multicentre Nationwide Registry.

Szymon Jonik1, Maciej Mazurek1, Bartosz Rymuza1

  • 11st Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland.

Journal of Clinical Medicine
|November 27, 2025
PubMed
Summary

Repeat transcatheter aortic valve implantation (redo-TAVI) is safe and effective in Poland. This study found low short-term adverse events, but highlighted a need for further investigation into late strokes and bicuspid anatomy.

Keywords:
bioprosthesis failureindex TAVIprocedure failureredo-TAVIvalve-in-valve procedure

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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Medical Technology

Background:

  • Transcatheter aortic valve implantation (TAVI) is a standard treatment for aortic stenosis.
  • Repeat TAVI (redo-TAVI) is increasingly performed due to transcatheter heart valve (THV) failure.
  • Patient selection and outcomes for redo-TAVI require further evaluation, especially in specific populations.

Purpose of the Study:

  • To evaluate the safety and efficacy of repeat transcatheter aortic valve implantation (redo-TAVI) in the Polish population.
  • To analyze periprocedural variables and long-term outcomes of patients undergoing redo-TAVI.
  • To identify factors associated with redo-TAVI outcomes.

Main Methods:

  • A multicentre nationwide registry study (ClinicalTrials.gov identifier, NCT03361046) included high-risk patients undergoing redo-TAVI.
  • Data collected included patient characteristics, procedural details, and short- and long-term outcomes.
  • Follow-up data were analyzed to assess valve function, complications, and mortality.

Main Results:

  • Thirty-two patients underwent redo-TAVI, with a mean age of 75 years; 62.5% were male.
  • The mean time from index TAVI to redo-TAVI was 4.7 years; common reasons for failure were THV dysfunction (78.1%) and procedural failure (21.9%).
  • Redo-TAVI resulted in none/mild regurgitation (90.6%) and low mean gradients (13.1 mmHg). Short-term adverse events were low, with 1-year cardiovascular and all-cause mortality at 9.4% and 15.6%, respectively. A notable finding was a 15.6% incidence of late non-procedural stroke.

Conclusions:

  • Redo-TAVI in Poland appears safe and effective, with favorable short-term outcomes.
  • Native bicuspid aortic anatomy was frequently observed, potentially influencing outcomes.
  • The occurrence of late stroke after redo-TAVI warrants further investigation in larger patient cohorts.