Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Derivatives of Inverse Trigonometric Functions

Derivatives of Inverse Trigonometric Functions

A ship tracking an approaching aircraft relies on geometric measurements to find out the aircraft’s position relative to the observer. By measuring the slant distance to the aircraft and the angle of elevation, the horizontal and vertical components of the distance can be obtained using trigonometric relationships. This geometric approach provides a basis for analyzing how the observed angle changes as the aircraft moves closer to the ship.To examine the mathematical behavior of the angle of...

Simpson's Rule II

Simpson's Rule II

In warehouse roofing applications, corrugated or curved metal sheets are commonly used to improve structural strength, water drainage, and ventilation efficiency. To accurately estimate material requirements and optimize design parameters, engineers must determine the curved surface area of these sheets. Because the sheet profiles often repeat smoothly along their length, they can be effectively approximated by parabolic curves, enabling the use of numerical integration techniques for area...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Neoadjuvant Therapy in Locally Advanced Rectal Cancer-What Result Should We Expect?

Medicina (Kaunas, Lithuania)·2026

Same author

From Static to Dynamic: Adaptive Molecular Subtyping in Treated Breast Cancers-Evidence from Single-Center Retrospective Cohort Study.

Cancers·2026

Same author

Phyllodes Tumor of the Breast: A Case Report Regarding the Importance of Fast Interdisciplinary Management.

Reports (MDPI)·2025

Same author

Quality of Life of Lung Cancer Patients with Immune-Related Endocrinopathies During Immunotherapy: A Prospective Study Based on the EORTC QLQ-C30 and QLQ-LC13 Questionnaires in Romania.

Current oncology (Toronto, Ont.)·2025

Same author

Immunohistochemistry Analysis in Inflammatory Bowel Disease-Should We Bring to Light Interleukin-10?

Biomedicines·2025

Same author

Therapeutic Management of Locally Advanced Rectal Cancer: Existing and Prospective Approaches.

Journal of clinical medicine·2025

Search research articles

Related Experiment Video

Updated: May 15, 2026

Stereotactic Radiosurgery for Gynecologic Cancer

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Optimizing SRS for Brain Metastases: Understanding the Volume-Gradient Index Relationship.

Tia Popescu-Bârhală^1,2, Ionuţ Dumitru², Mihai-Ştefan Bârhală^1,2

¹Faculty of Physics, University of Bucharest, Atomiștilor Street 405, 077125 Măgurele, Romania.

Journal of Clinical Medicine

|November 27, 2025

Summary

Target volume significantly impacts Stereotactic Radiosurgery (SRS) and Stereotactic Radiotherapy (SRT) plan quality metrics like Gradient Index (GI) and Gradient Measure (GM). Multiple targets also influence these metrics.

Keywords:

evaluation quality metrics stereotactic radiotherapy treatment planning

More Related Videos

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Related Experiment Videos

Last Updated: May 15, 2026

Stereotactic Radiosurgery for Gynecologic Cancer

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

Area of Science:

Medical Physics
Radiation Oncology
Radiosurgery

Background:

Developing high-quality dosimetric standards for SRS-SRT plans is crucial.
Key questions involve selecting plan quality metrics, identifying influential factors, and optimizing plan geometry.
This study focuses on factors influencing plan quality metrics.

Purpose of the Study:

To establish a framework for generating high-quality SRS-SRT plans.
To identify key factors influencing plan quality metrics.
To understand the relationship between target volume and plan quality.

Main Methods:

Retrospective analysis of 200 SRS-SRT target volumes from two institutions.
Development of Linear Regression models to assess plan quality metric variability.
Statistical analysis to identify the most significant regressors.

Main Results:

Target volume (TV) and multiple targets (MT) were identified as primary influences on plan quality.
Doubling TV significantly decreases Gradient Index (GI) and moderately increases Gradient Measure (GM).
The models explained 85% of GI variation and 84% of GM variation.

Conclusions:

Gradient Index (GI) is a more sensitive metric than Gradient Measure (GM) for small lesions in sub-CC SRS targets.
Dose per fraction did not significantly affect plan quality metrics.
Treating multiple targets increases GI and GM, independent of target volume.