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Vacuum-Assisted Wound Therapy in Bothrops Snakebite Injuries: A Case Series from the Brazilian Amazon
Roberto C C Carbonell1,2,3, Allan Q Garcês-Filho2, Luis E B Galan2,3
1Graduate Program in Bioscience and Biotechnology Applied to Pharmacy, School of Pharmaceutical Sciences, São Paulo State University (UNESP), Araraquara 19060-900, SP, Brazil.
Journal of Clinical Medicine
|November 27, 2025
Summary
Vacuum-Assisted Wound Therapy (VAWT) significantly improved healing in complex Bothrops snakebite wounds in Brazil. This approach promotes faster tissue repair and reduces amputation risk, offering a promising alternative to conventional treatments.
Area of Science:
- Toxicology
- Wound Healing
- Clinical Medicine
Background:
- Snakebites, particularly from Bothrops species in Roraima, Brazil, pose a significant health burden.
- Venom toxins cause severe systemic complications and complex wounds, leading to disability.
- Current antivenoms are insufficient to prevent local tissue damage, resulting in prolonged hospitalizations and high costs.

