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Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

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In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
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Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

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Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
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Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
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Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

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In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Other Pulmonary Disorders01:17

Other Pulmonary Disorders

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Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Treatable Traits In Pediatric Interstitial Lung Diseases: Bridging The Gap To Tailored Therapeutics.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Treatable Traits In Pediatric Interstitial Lung Diseases: Bridging The Gap To Tailored Therapeutics.

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Treatable Traits in Pediatric Interstitial Lung Diseases: Bridging the Gap to Tailored Therapeutics.

Giuseppe Fabio Parisi1, Maria Papale1, Giulia Pecora1

  • 1Pediatric Respiratory Unit, Department of Clinical and Experimental Medicine, San Marco Hospital, University of Catania, 95121 Catania, Italy.

Journal of Clinical Medicine
|November 27, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

The treatable traits framework offers personalized care for children with interstitial lung diseases (chILD) by targeting specific clinical features. This approach aims to improve early diagnosis and tailor treatments for better outcomes in pediatric lung disorders.

Keywords:
genetic disordersimmune dysregulationmultidisciplinary carepediatric interstitial lung disease

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Area of Science:

  • Pediatric Pulmonology
  • Rare Diseases
  • Genetics

Background:

  • Pediatric interstitial lung diseases (chILD) are rare, complex disorders with varied causes and clinical presentations.
  • Current diagnosis-based management can delay targeted therapies, necessitating a more precise approach.

Purpose of the Study:

  • To adapt the "treatable traits" framework for pediatric ILD management.
  • To identify and define key treatable traits in children with ILD.
  • To outline diagnostic and management strategies for these traits.

Main Methods:

  • Narrative review synthesizing existing evidence and expert consensus.
  • Identification of key treatable traits in pediatric ILD.
  • Description of diagnostic pathways and targeted management strategies.
personalized medicine
pulmonary hypertension
treatable traits

Main Results:

  • Key treatable traits identified include genetic/surfactant dysfunction, immune issues, pulmonary hypertension, hypoxemia, aspiration, growth deficits, and environmental factors.
  • Diagnostic tools include genetic testing, bronchoalveolar lavage, imaging, and functional assessments.
  • Management strategies are tailored to each identified trait.

Conclusions:

  • A trait-based approach enables personalized care, improving early diagnosis and intervention for pediatric ILD.
  • Multidisciplinary collaboration, standardized protocols, and research are crucial for successful implementation.
  • This precision medicine strategy holds promise for altering disease trajectories in pediatric ILD.