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The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
Published on: June 29, 2019
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Long-Term Outcomes After Therapeutic Induction in Patients with Functional Dyspepsia
Takayuki Kitano1, Toshihiko Tomita1, Masatoshi Mieno1
1Department of Gastroenterology, Faculty of Medicine, Hyogo Medical University, Nishinomiya 663-8501, Hyogo, Japan.
Journal of Clinical Medicine
|November 27, 2025
Summary
Functional dyspepsia (FD) often requires long-term treatment. Baseline depression and abdominal pain predict poor outcomes, highlighting the need for integrated psychological and medical management for functional dyspepsia patients.
Area of Science:
- Gastroenterology
- Psychiatry
Background:
- Functional dyspepsia (FD) is a common gastrointestinal disorder.
- Long-term outcomes and treatment resistance factors in FD require further investigation.
Purpose of the Study:
- To evaluate long-term outcomes of FD over 3 years.
- To identify factors associated with treatment resistance in FD.
Main Methods:
- Retrospective analysis of 111 FD patients diagnosed via Rome IV criteria.
- Assessment of gastrointestinal symptoms (GSRS), psychological distress (HADS), and quality of life (SF-8).
- Evaluation of treatment response at 1 and 3 years with various therapeutic approaches.
Main Results:
- Symptom improvement rates were 50.5% at 1 year and 80.2% at 3 years.
- Higher baseline HADS-Depression and GSRS-Abdominal Pain scores predicted treatment resistance.
- HADS-Depression and GSRS-Abdominal Pain were independent predictors of poor long-term outcomes.
Conclusions:
- FD management necessitates prolonged therapeutic strategies.
- Early psychological assessment and integrated care are crucial for improving FD outcomes.
- Depressive symptoms and abdominal pain at baseline are key indicators for treatment resistance in FD.
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