Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

185
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
185

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Low-Temperature xTB-MD-DFT Screening of Functionalized Oxide Surface-Patch Models (TiO<sub>2</sub>, ZnO, CeO<sub>2</sub>) for Hydrocarbon Association and Microbial-Proxy Perturbation Assessment in Cold Bioremediation.

Nanomaterials (Basel, Switzerland)·2026
Same author

Bioactive Profile, Antioxidant, and Antimicrobial Activity of Sweet and Hot Peppers at Different Stages of Ripeness.

Antioxidants (Basel, Switzerland)·2026
Same author

Rambutan (<i>Nephelium lappaceum</i> L.) Shell as a Source of Polyphenols: Chemical Characterization and Biological Activities.

Molecules (Basel, Switzerland)·2026
Same author

Detection of Adenoviral <i>E1A</i> Gene in Guthrie Cards for Insights into Pediatric Cancer Origin.

International journal of molecular sciences·2026
Same author

Functional Evaluation, Antioxidant, Antimicrobial, Antibiofilm, and Haemolytic Capacity of <i>Calathea lutea</i> (Bijao) and <i>Calathea inocephala</i> (Shutupipanga) Leaves.

Antioxidants (Basel, Switzerland)·2026
Same author

Visible-Light-Driven Photocatalytic Degradation of Dyes and Ciprofloxacin Using Coral-like β-Bi<sub>2</sub>O<sub>3</sub>.

Molecules (Basel, Switzerland)·2026

Related Experiment Video

Updated: Jan 10, 2026

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods
06:12

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods

Published on: April 14, 2023

947

Bioactive Phenolic Compounds from Rambutan (Nephelium lappaceum L.) Shell: Encapsulation, Structural Stability, and

Carlos Barba-Ostria1,2, Orestes López3, Alexis Debut4,5

  • 1Escuela de Medicina, Colegio de Ciencias de la Salud Quito, Universidad San Francisco de Quito (USFQ), Quito 170901, Ecuador.

International Journal of Molecular Sciences
|November 27, 2025
PubMed
Summary

Rambutan shell phenolics were microencapsulated using spray drying, creating a stable, bioactive ingredient. This valorized waste product shows antioxidant, antibacterial, and biofilm inhibition properties for food and biomedical applications.

Keywords:
Nephelium lappaceum shellantibiofilmantimicrobialantioxidanthemocompatibilitymicroencapsulationnutraceutical applicationsphenolic acidsspray drying

More Related Videos

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis
10:03

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis

Published on: August 15, 2025

594
Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

4.3K

Related Experiment Videos

Last Updated: Jan 10, 2026

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods
06:12

Using Multiple Light Scattering to Examine the Stability of Phyllanthus emblica L. Extracts Obtained with Different Extraction Methods

Published on: April 14, 2023

947
Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis
10:03

Comparative Study on the Polysaccharide Contents and Antioxidant Activities of Hippophae rhamnoides subsp. sinensis and Hippophae gyantsensis

Published on: August 15, 2025

594
Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults
14:39

Semi-Targeted Ultra-High-Performance Chromatography Coupled to Mass Spectrometry Analysis of Phenolic Metabolites in Plasma of Elderly Adults

Published on: April 22, 2022

4.3K

Area of Science:

  • Food Science and Technology
  • Biomaterials Engineering
  • Sustainable Chemistry

Background:

  • Rambutan (Nephelium lappaceum) shell is an agro-industrial byproduct rich in phenolic acids and anthocyanins.
  • Direct utilization of these compounds is hindered by instability and poor bioavailability.
  • Valorization of this waste stream can contribute to sustainable production and health goals.

Purpose of the Study:

  • To extract phenolic-rich fractions from rambutan shell.
  • To develop stable, microencapsulated forms of these phenolics using spray drying.
  • To evaluate the bioactivity, safety, and potential applications of the microcapsules.

Main Methods:

  • Extraction of phenolic compounds from rambutan shell.
  • Production of maltodextrin microcapsules via spray drying.
  • Characterization using FTIR, SEM, and XRD; assessment of encapsulation efficiency, antioxidant capacity (DPPH), antimicrobial activity, biofilm inhibition, and hemolysis.

Main Results:

  • Successful chemical entrapment and amorphization confirmed by FTIR, SEM, and XRD.
  • High encapsulation efficiency and significant antioxidant capacity (DPPH assay).
  • Selective bactericidal activity against Pseudomonas aeruginosa and Burkholderia cepacia; strong inhibition of Staphylococcus aureus and Listeria monocytogenes biofilms; negligible hemolysis (<2%).
  • Moderate in vitro antitumor effects with low selectivity.

Conclusions:

  • Spray-dried microcapsules enhance the stability and bioavailability of rambutan shell phenolics.
  • The formulation exhibits potent antioxidant, antimicrobial, and antibiofilm properties, alongside hemocompatibility.
  • This approach offers a scalable method for valorizing agricultural waste into functional ingredients for food and biomedical sectors, aligning with Sustainable Development Goals 3 and 12.