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Updated: Jul 9, 2026

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A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
Published on: November 12, 2019
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Special Issue "Targeting CAR T-Cell Therapy: Molecular Research and Its Future Implication"
1Comprehensive Cancer Centre, School of Cancer and Pharmaceutical Medicine, King's College London, London SE5 8AF, UK.
International Journal of Molecular Sciences
|November 27, 2025
Summary
Chimeric antigen receptor (CAR) T-cell therapy is a groundbreaking cancer treatment. This therapy involves genetically modifying a patient's T-cells to target and destroy cancer cells effectively.
Area of Science:
- Oncology
- Immunotherapy
- Cellular Therapy
Background:
- Chimeric antigen receptor (CAR) T-cell therapy has emerged as a significant advancement in cancer treatment.
- CAR T-cell therapy represents a novel approach to harnessing the immune system against malignancies.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

