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Injuries in Artistic Gymnastics: Etiology, Prevention Strategies, and Multifactorial Perspectives-A Systematic Review
Raid Mekić1, Vladan Milić1, Oliver Radenković1
1Department of Biomedical Sciences, State University of Novi Pazar, 36300 Novi Pazar, Serbia.
International Journal of Molecular Sciences
|November 27, 2025
Summary
Artistic gymnastics injuries are multifactorial. Understanding biomechanical, molecular, and genetic factors is key for effective injury prevention and performance optimization in gymnasts.
Area of Science:
- Sports Medicine
- Exercise Physiology
- Genetics
Background:
- Artistic gymnastics has a high incidence of acute and chronic injuries.
- Previous research has focused on biomechanics and training, neglecting molecular and genetic factors.
- The multifactorial nature of gymnastics injuries necessitates a broader investigation.
Purpose of the Study:
- To systematically review evidence on the causes, mechanisms, and prevention of artistic gymnastics injuries.
- To emphasize biomechanical, molecular, and genetic determinants of injury risk and performance.
- To provide a comprehensive overview of current research for injury prevention strategies.
Main Methods:
- Systematic review following PRISMA 2020 guidelines, registered on PROSPERO.
- Searched PubMed, KoBSON, and Google Scholar (2015-2025) for keywords: gymnastics injuries, overuse injuries, injury prevention, biomechanics, IL-6, TNF-α, miRNA biomarkers.
- Analyzed 19 studies on injury incidence, localization, mechanisms, and molecular/genetic associations.
Main Results:
- Most injuries affect upper and lower extremity joints, especially during puberty and high competition levels.
- Repetitive loading, poor technique, and inadequate recovery are primary etiological factors.
- Biomarkers (IL-6, TNF-α, miRNAs) linked to inflammation; genetic polymorphisms (ACTN3, ESR1, CYP19A1) associated with flexibility, strength, and injury susceptibility.
Conclusions:
- Injury prevention requires a personalized, multidisciplinary approach integrating biomechanical, clinical, molecular, and genetic data.
- Molecular and genetic profiling can improve early detection of overuse injuries.
- Optimizing gymnast health and performance necessitates incorporating advanced profiling into training and rehabilitation.

