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A Novel Therapeutic Target for Pediatric Pneumonia: Sestrin2

Hatice Uygun1, Zeynep Nur Çiçek2, Kenan Ercan3

  • 1Department of Pediatric Infectious Disease, School of Medicine, Gaziantep University, Gaziantep 27310, Turkey.

Medicina (Kaunas, Lithuania)
|November 27, 2025
PubMed

Insights

Pediatric pneumonia patients show lower Sestrin2 (SESN2) levels, linked to increased oxidative stress. Boosting SESN2 may reduce complications and serve as a biomarker for childhood pneumonia.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Molecular Biology

Background:

  • Pneumonia complications' mechanisms remain unclear.
  • Sestrin2 (SESN2), an antioxidant protein, is implicated in various diseases.
  • The role of SESN2 in pediatric pneumonia requires investigation.

Purpose of the Study:

  • To investigate the relationship between Sestrin2 expression and pneumonia in hospitalized children.
  • To explore the correlation between Sestrin2, oxidative stress, and age in pediatric pneumonia.

Main Methods:

  • Compared Sestrin2 levels and reactive oxygen species (ROS) in 39 pediatric pneumonia patients and 37 healthy controls.
  • Analyzed correlations between Sestrin2, ROS, and patient age.

Main Results:

  • Pediatric pneumonia patients exhibited significantly lower SESN2 levels compared to controls (p=0.039).
  • A strong positive correlation was found between SESN2 and ROS (r=0.743, p=0.001).
  • A moderate negative correlation was observed between SESN2 and age (r=-0.467, p=0.003).

Conclusions:

  • Decreased SESN2 levels may contribute to pediatric pneumonia manifestations.
  • Increasing SESN2 levels could mitigate pneumonia-related complications by reducing oxidative stress.
  • SESN2 shows potential as a clinical biomarker and prognostic factor for pediatric pneumonia.

Keywords:
Sestrin2childrenoxidative stresspneumoniareactive oxygen species

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