Globicatella sanguinis-A Literature Review of Case Reports

Globicatella sanguinis is a rare and distinct Gram-positive coccus, first described in 1992, and part of the normal human microbiota. Although infrequent, it can cause serious infections such as urinary tract infections, meningitis, and endocarditis, particularly in vulnerable populations. Due to its atypical biochemical profile and frequent misidentification by conventional diagnostic systems, accurate identification is essential to avoid inappropriate treatment. This narrative review analyzes 21 published case reports involving 51 patients, with many cases linked to invasive procedures or immunosuppression. The review emphasizes the need for molecular diagnostic tools and individualized antimicrobial therapy, while also identifying gaps in current knowledge that warrant further investigation.