Related Experiment Video

Updated: Jul 11, 2026

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.7K

Role of Final Kissing Balloon Inflation in Left Main Distal Bifurcation Single Stenting: Insights from Angiographic

En Chen1, Danqing Hu2, Hong Zheng1

  • 1Department of Cardiology, Fujian Medical University Union Hospital, Fujian Cardiovascular Medicine Center, Fujian Institute of Coronary Artery Disease, Fujian Cardiovascular Research Center, Fujian Medical University Heart Center, Fuzhou 350001, China.

Medicina (Kaunas, Lithuania)
|November 27, 2025
PubMed

Insights

Final kissing balloon inflation (FKBI) reduces long-term restenosis in left main stenting by improving coronary microcirculation. FKBI also stabilized microcirculatory resistance, unlike simple crossover stenting.

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Coronary Microcirculation

Background:

  • The role of final kissing balloon inflation (FKBI) in single stenting for left main (LM) interventions is debated.
  • No studies have evaluated FKBI's impact on angiographic restenosis concerning coronary microcirculation.

Purpose of the Study:

  • To investigate if FKBI reduces angiographic restenosis in LM-left anterior descending (LAD) single stenting.
  • To analyze temporal changes in the angiography-derived index of microcirculatory resistance (AMR) and their effect on restenosis.
  • To assess FKBI's impact after propensity score matching (PSM) for baseline AMR.

Main Methods:

  • Calculated AMR from coronary angiography (LM-left circumflex [LCX]) pre- and post-procedure and at follow-up.
  • Assessed long-term angiographic restenosis using percent diameter stenosis (DS%).
  • Utilized PSM to balance baseline characteristics, including pre-procedural AMR.

Main Results:

  • After PSM, the FKBI group showed lower long-term DS% in the LM and LAD.
  • Long-term AMR increased in the simple crossover group but remained stable in the FKBI group.
  • Pre-procedural AMR predicted LAD restenosis in the simple crossover group but not after FKBI.

Conclusions:

  • FKBI reduces long-term angiographic restenosis in LM-LAD single stenting after PSM, including pre-procedural AMR.
  • FKBI is associated with lower long-term AMR compared to simple crossover.
  • FKBI may negate the predictive value of pre-procedural AMR for future LAD progression.

Keywords:
angiography-derived index of microcirculatory resistancecoronary microcirculationfinal kissing balloon inflationleft main coronary bifurcation lesionsimple crossoversingle stenting

More Related Videos

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis06:59

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis

Published on: August 26, 2025

510

Related Concept Videos

Blood Flow01:29

Blood Flow

Blood is pumped by the heart into the aorta, the largest artery in the body, and then into increasingly smaller arteries, arterioles, and capillaries. The velocity of blood flow decreases with increased cross-sectional blood vessel area. As blood returns to the heart through venules and veins, its velocity increases. The movement of blood is encouraged by smooth muscle in the vessel walls, the movement of skeletal muscle surrounding the vessels, and one-way valves that prevent backflow.
Heart Valves01:16

Heart Valves

The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Arteries and Arterioles01:16

Arteries and Arterioles

Arteries, the vasculature responsible for transporting blood from the heart, possess robust walls capable of enduring the elevated pressures exerted by the heartbeat. Arteries near the heart are especially thick-walled and enriched with elastic fibers across their three tunics, classifying them as elastic or conducting arteries. These arteries, usually with a diameter exceeding 10 mm, are characterized by their ability to dilate in response to the blood pumped from the heart's ventricles and...
Autoregulation of Blood Flow01:17

Autoregulation of Blood Flow

Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...