Related Experiment Video
Updated: Jan 10, 2026

A New Screening Method for the Directed Evolution of Thermostable Bacteriolytic Enzymes
Published on: November 7, 2012
Thermostable Proteases from Geobacillus: Production, Characterization, Structural Stability Mechanisms and
Meng Wang1,2, Jun-Wei Wang2, Jun-Hui Cheng3
1Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao 266071, China.
Abstract:
Proteases play key roles in many industrial processes and account for the majority of global enzyme sales. Geobacillus isolates from extreme environments such as marine hydrothermal vents are capable of producing high yields of proteases with thermophilic properties. Many proteases produced by Geobacillus species have been extensively studied, some of which have been purified and characterized. In addition, the high thermal stability largely depends on structural stability. Based on X-ray crystallography, several factors have been found to affect the structural stability of the thermostable proteases of Geobacillus. Moreover, the thermostable proteases of Geobacillus have a wide range of biotechnological applications, such as in detergent, food, bioremediation, leather-processing and textile industries. Therefore, this review focusses on the thermostable proteases of Geobacillus, including their characteristics, structural stability mechanisms and biotechnological applications. It will help the development of utilizing thermostable protease resources and enhancing their suitability for use in various industrial applications.
Related Concept Videos
Diversity of Archaea IV
Hyperthermophilic Bacteria
Diversity of Archaea III
Factors Influencing Microbial Growth: Temperature
Diversity of Archaea I
Overview of Archaea

