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Advances in Pseudomonas aeruginosa-Induced Programmed Cell Death and Potential Targeted Treatment Strategies

Chunjiang Tan1,2, Yifeng Luo1,2,3

  • 1Division of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China.

Microorganisms
|November 27, 2025
PubMed

Insights

Pseudomonas aeruginosa infections trigger programmed cell death (PCD) pathways, including PANoptosis. This review details advances in understanding P. aeruginosa-induced PANoptosis and proposes new therapeutic strategies.

Area of Science:

  • Microbiology
  • Immunology
  • Molecular Biology

Background:

  • Pseudomonas aeruginosa (P. aeruginosa) causes significant nosocomial infections.
  • P. aeruginosa employs programmed cell death (PCD) pathways, including apoptosis, pyroptosis, necroptosis, ferroptosis, and PANoptosis, as a pathogenic mechanism.
  • PANoptosis, a newly identified PCD pathway, is mediated by PANoptosome complexes and their regulators.

Purpose of the Study:

  • To review recent advances in P. aeruginosa-induced PANoptosis.
  • To provide mechanistic insights into PANoptosome sensor protein activation during P. aeruginosa infection.
  • To explore potential therapeutic targets for P. aeruginosa-induced PCD.

Main Methods:

  • Literature review focusing on P. aeruginosa-induced programmed cell death.
  • Analysis of mechanistic insights into PANoptosome activation.
  • Discussion of pharmacological compounds targeting P. aeruginosa-induced PCD.

Main Results:

  • Summarizes upregulation and activation of PANoptosome sensor proteins and regulators in P. aeruginosa infection.
  • Highlights mechanistic links between P. aeruginosa cytotoxicity and various PCD forms.
  • Identifies potential pharmacological agents for targeting P. aeruginosa-induced PANoptosis.

Conclusions:

  • Advances in understanding P. aeruginosa-induced PANoptosis are crucial for combating infections.
  • Targeting P. aeruginosa-induced PCD, especially PANoptosis, offers novel therapeutic avenues.
  • Further research is needed to develop effective therapeutics against P. aeruginosa.
Keywords:
P. aeruginosaPANoptosisapoptosisferroptosisnecroptosisprogrammed cell deathpyroptosis

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