Related Experiment Video
Updated: Jan 10, 2026
09:14
An Improved and High Throughput Respiratory Syncytial Virus RSV Micro-neutralization Assay
Published on: January 26, 2019
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Inactivation of Respiratory Syncytial Virus by Ozone Generated via Dielectric Barrier Discharge Technology with
Akikazu Sakudo1, Ryoya Moriyama2, Masanori Nieda2
1School of Veterinary Medicine, Okayama University of Science, Imabari 794-8555, Ehime, Japan.
Microorganisms
|November 27, 2025
Summary
Ozone gas effectively inactivates respiratory syncytial virus (RSV) on surfaces. This safe, non-contact method shows potential for infection control in pediatric settings.
Area of Science:
- Environmental Science
- Virology
- Infectious Diseases
Background:
- Respiratory syncytial virus (RSV) causes severe respiratory infections in children.
- Current disinfectants like alcohol and detergents pose safety risks in pediatric environments.
- Ozone (O3) is used for disinfection but its efficacy against RSV is not well-established.
Purpose of the Study:
- To investigate the inactivation of RSV using a dielectric barrier discharge (DBD)-based ozone generator.
- To evaluate the safety and efficacy of ozone for surface disinfection of RSV.
Main Methods:
- RSV A2 strain was exposed to low-concentration ozone (0.5 ppm) for 1 hour.
- Infectivity assays (TCID50) and biochemical analyses (RNA, F protein) were performed.
- Controlled temperature and humidity conditions were maintained during exposure.
Main Results:
- Ozone exposure significantly reduced RSV infectivity by over 6 logs (TCID50).
- Biochemical analysis revealed damage to RSV genomic RNA and F protein.
- Ozone effectively inactivated RSV on glass coverslips.
Conclusions:
- The SFG1210 ozone generator is a potentially effective tool for RSV surface disinfection.
- Ozone offers a safe, non-contact, and practical approach for infection control.
- Ozone inactivates RSV by damaging its genome and surface proteins.
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