Jove
Visualize
Contact Us

Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

176
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
176

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

AI in Membrane Design and Optimization for Hydrogen Fuel Cells.

Membranes·2026
Same author

Mitigation Techniques of Membranes' Biofouling in Bioelectrochemical Cells (BEC Cells): Recent Advances.

Membranes·2025
Same author

Alginate-tungsten trioxide-reduced graphene-based membranes for PEM fuel cells operating above the boiling point of water.

RSC advances·2025
Same author

Development and characterization of novel flexible cellulose electrodes for electrophysiological monitoring.

RSC advances·2025
Same author

MXene-Based Flexible Electrodes for Electrophysiological Monitoring.

Sensors (Basel, Switzerland)·2024
Same author

Nanogel-based composites for bacterial antibiofilm activity: advances, challenges, and prospects.

RSC advances·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jan 10, 2026

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
10:33

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Published on: July 23, 2016

11.0K

Recent Advances on Chitosan-Based Nanoparticles for Brain Drug Delivery.

Chihab Ezzaki1, Anas Chaari1, Amani Al-Othman1,2,3

  • 1Biomedical Engineering Graduate Program, College of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.

Polymers
|November 27, 2025
PubMed
Summary

Chitosan-based nanoparticles (CNPs) offer a promising solution for delivering drugs across the blood-brain barrier (BBB) to treat neurological disorders. These nanoparticles enhance drug permeability and enable targeted delivery, improving therapeutic outcomes.

Keywords:
brain drug deliverybrain tumorchitosan nanoparticles (CNPs)intranasal routeneuro-degenerative disorders

More Related Videos

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

7.9K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

3.0K

Related Experiment Videos

Last Updated: Jan 10, 2026

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes
10:33

Delivery of Therapeutic siRNA to the CNS Using Cationic and Anionic Liposomes

Published on: July 23, 2016

11.0K
Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells
10:01

Modeling Brain Metastasis by Internal Carotid Artery Injection of Cancer Cells

Published on: August 2, 2022

7.9K
Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment
09:02

Author Spotlight: Innovative Cancer Therapies with Iron Oxide Nanoparticles for Glioblastoma Treatment

Published on: September 27, 2024

3.0K

Area of Science:

  • Nanomedicine
  • Neuroscience
  • Biomaterials

Background:

  • The blood-brain barrier (BBB) severely limits drug delivery to the brain for neurological disorder treatment.
  • Chitosan-based nanoparticles (CNPs) show potential due to their biocompatibility and biodegradability.
  • CNPs can enhance drug permeability across the BBB.

Purpose of the Study:

  • To review the design and application of CNPs for brain-targeted drug delivery.
  • To explore mechanisms of CNP-mediated drug transport across the BBB.
  • To discuss surface modifications for improved specificity and therapeutic efficacy.

Main Methods:

  • Review of existing literature on CNPs for brain drug delivery.
  • Analysis of CNP mechanisms: adsorptive-mediated and receptor-mediated endocytosis.
  • Discussion of intranasal delivery routes for direct brain targeting.

Main Results:

  • CNPs facilitate controlled drug release, enhance stability, and reduce side effects.
  • Effective for treating Alzheimer's, Parkinson's, brain tumors, and ischemic stroke.
  • Capable of encapsulating diverse therapeutic agents (drugs, genetic materials).

Conclusions:

  • CNPs are effective for brain drug delivery, offering controlled release and stability.
  • Intranasal delivery bypasses systemic circulation for direct brain targeting.
  • Further research is needed on long-term effects, biodistribution, and clearance of CNPs.