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Specific Hepatorenal Toxicity and Cross-Species Susceptibility of Eight Representative Pesticides

Yue Liu1, Ning Xu2, Xinyu Song3

  • 1School of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.

Toxics
|November 27, 2025
PubMed

Insights

Pesticide exposure causes liver and kidney damage, with varying effects across species and cell types. NRK cells showed unique resistance, while the MRP2 transporter was downregulated in most tested cells.

Area of Science:

  • Toxicology
  • Cell Biology
  • Environmental Health

Background:

  • Chronic pesticide exposure presents hepatorenal toxicity risks.
  • A systematic comparison of pesticide effects across species and tissues is needed.

Purpose of the Study:

  • To systematically evaluate the cytotoxicity of eight pesticides.
  • To compare species- and tissue-specific responses to pesticide exposure.
  • To investigate the mechanistic insights into pesticide-induced toxicity.

Main Methods:

  • Utilized human (CCC-HEL-1, 293T) and rodent (IAR, NRK) cellular models.
  • Assessed cytotoxicity and employed principal component analysis for response pattern identification.
  • Conducted mechanistic investigations using organ-specific biomarkers and transporter analysis (MRP2).

Main Results:

  • Significant variations in pesticide potency observed; chlorothalonil was most toxic, chlorpyrifos least toxic.
  • Distinct species- and tissue-specific response patterns identified, with NRK cells showing unique resistance.
  • Organ-specific biomarker alterations (hepatic ALP, renal KIM-1) and tissue-specific MRP2 transporter downregulation noted.

Conclusions:

  • Findings provide mechanistic insights into pesticide-specific toxicity and cross-species susceptibility.
  • Data supports improved human health risk assessment for food safety and toxicology.
  • Highlights the importance of considering species and tissue differences in pesticide toxicity evaluations.
Keywords:
biomarkerscross-species comparisonhepatorenal toxicityin vitro toxicologypesticide

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