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Small Interfering RNA Carriers for Oncotherapy: A Preclinical Overview
Liliana Aranda-Lara1, Alondra Escudero-Castellanos1, Maydelid Trujillo-Nolasco1
1Laboratorio de Investigación en Teranóstica, Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca 50180, Mexico.
Pharmaceutics
|November 27, 2025
Summary
Synthetic small interfering RNA (siRNA) formulations show promise for cancer therapy by silencing specific genes. Research focuses on developing stable, bioavailable siRNA delivery systems for personalized, genomics-guided cancer treatments.
Area of Science:
- Oncology
- Gene Therapy
- Nanotechnology
Background:
- Small interfering RNA (siRNA) is a key area of research in oncology.
- While not yet FDA-approved for cancer, siRNA formulations demonstrate significant potential for tumor remission.
Purpose of the Study:
- To review synthetic siRNA formulations for systemic cancer gene silencing.
- To provide an overview of current siRNA-based cancer therapy designs.
Main Methods:
- Conducted a literature search using keywords: "siRNA", "therapy", and "cancer".
- Classified reviewed works by topic for comprehensive analysis.
Main Results:
- Discusses siRNA design, chemical modifications for stability and bioavailability, and nanocarrier integration.
- Examines various siRNA formulations, including conjugates and nanoparticles (organic, inorganic, hybrid), detailing their pros and cons.
- Highlights the role of nanosystems in dual therapy and personalized cancer treatment.
Conclusions:
- Personalized, genomics-guided cancer therapy is the future of oncology.
- siRNA offers a flexible platform for targeting oncogenes in patient-specific treatments.
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