Related Experiment Video
Updated: Jan 10, 2026
08:06
Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays
Published on: November 10, 2016
7.9K
Artificial Intelligence (AI) in Pharmaceutical Formulation and Dosage Calculations.
1Department of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine, Suwanee, GA 30024, USA.
Pharmaceutics
|November 27, 2025
Summary
Artificial intelligence (AI) is revolutionizing pharmaceutical sciences, enhancing drug formulation and dosage calculations. AI technologies like machine learning (ML) improve accuracy, efficiency, and personalization in drug development.
Area of Science:
- Pharmaceutical Sciences
- Computational Chemistry
- Drug Development
Background:
- Traditional pharmaceutical sciences face challenges in accuracy, efficiency, and personalization.
- Artificial intelligence (AI) offers innovative solutions to these challenges.
Purpose of the Study:
- To provide a comprehensive overview of AI applications in pharmaceutical calculations.
- To explore AI's role in drug formulation, dosage calculation, and personalized medicine.
Main Methods:
- Review of current AI technologies including machine learning (ML), deep learning (DL), and natural language processing (NLP).
- Exploration of AI applications in predicting drug properties, excipient optimization, formulation design, and PK/PD modeling.
Main Results:
- AI enhances accuracy, efficiency, and personalization in pharmaceutical calculations.
- AI is applied in predicting drug properties, optimizing excipients, and designing formulations.
- AI aids in PK/PD modeling, real-time dose adjustment, and precision medicine.
Conclusions:
- AI significantly impacts automated decision-making, quality control, and regulatory compliance in pharmaceutical formulation.
- Emerging trends include AI-assisted 3D printing and integration with wearable technologies for personalized therapeutics.
- AI holds transformative potential for the future of pharmaceuticals and personalized medicine.
Related Concept Videos
01:22Biopharmaceutical Factors Influencing Drug Product Design: Overview
222
Rational drug product design integrates knowledge of the drug’s physicochemical properties, formulation components, manufacturing techniques, and intended route of administration. Each factor influences the drug’s performance, including how it is released, absorbed, and eliminated in the body.The physicochemical properties of a drug—such as solubility, stability, and particle size—affect its compatibility with excipients and the choice of dosage form. Excipients, though...
222
01:28Dosage Regimens: Designs and Approaches
246
Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
246
01:26Pharmaceutical Equivalents
171
As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
171
01:01Dosage Regimens: Partial Pharmacokinetic Parameters
138
It is not uncommon for complete drug pharmacokinetic profiles to remain elusive in pharmacokinetics. This necessitates certain educated assumptions by pharmacokineticists to determine appropriate dosage regimens without comprehensive pharmacokinetic data from animal or human studies. One prevalent assumption is setting the bioavailability factor, denoted as F, to 1 or 100%. This assumption caters to the scenario where a drug doesn't achieve full systemic absorption, resulting in the patient...
138
01:19Dosage Interval and Administration Route: Determination Methods
204
A medication’s effectiveness largely depends on its appropriate dosage and the route of administration. Dosage ensures that a sufficient drug concentration is maintained in the bloodstream to elicit the desired therapeutic effect without causing toxicity. The route of administration affects the drug's bioavailability, rate of absorption, and onset of action, which are crucial for achieving optimal therapeutic outcomes. Drug dosage calculations are critical to tailoring therapy to...
204
01:24Dosage Regimen: Individualization
156
Individualization in dosing regimens is the customization of medication doses for individual patients. Its necessity arises from the goal of maximizing therapeutic benefits while minimizing risks. This approach is pivotal because human responses to drugs can vary widely; what is effective for one person may be inadequate or excessive for another. Interpatient (intersubject) variability refers to differences in drug responses between individuals, while intrapatient (intrasubject) variability...
156