Nanostructured Delivery Systems for Curcumin: Improving Bioavailability and Plaque-Targeting Efficacy in

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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis

Published on: November 17, 2017

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Yu Liu1, Tengfei Yu2, Chao Zhang3

  • 1International Education Department, Henan Vocational College of Nursing, Anyang 455000, China.

Pharmaceutics
|November 27, 2025
PubMed

Insights

Cardiovascular disease (CVD) is a major global killer. This review explores curcumin

Area of Science:

  • Biomedical Science
  • Pharmacology
  • Natural Products

Background:

  • Cardiovascular disease (CVD) is the leading cause of global mortality, accounting for over 40% of non-communicable disease deaths.
  • Atherosclerosis (AS), a primary contributor to CVD, is a chronic inflammatory condition driven by factors like hyperlipidemia and hypertension.
  • Natural bioactive compounds are increasingly recognized for their therapeutic potential in managing complex diseases.

Purpose of the Study:

  • To review traditional pharmacological treatments for atherosclerosis (AS).
  • To elucidate the therapeutic mechanisms of curcumin (Cur) in AS.
  • To introduce novel nanoformulations of Cur for enhanced AS therapy.

Main Methods:

  • Literature review of pharmacological approaches for AS treatment.
  • Analysis of scientific data on curcumin's anti-inflammatory, lipid-lowering, and endothelial protective effects.
  • Exploration of emerging nanoformulations for curcumin delivery.

Main Results:

  • Curcumin exhibits significant anti-inflammatory, lipid-lowering, antihypertensive, and endothelial protective properties relevant to AS.
  • Curcumin's therapeutic mechanisms in AS involve modulating key inflammatory pathways.
  • Novel nanoformulations can overcome curcumin's limitations, improving its bioavailability and efficacy.

Conclusions:

  • Curcumin holds considerable promise as a therapeutic agent for atherosclerosis and related cardiovascular diseases.
  • Understanding curcumin's mechanisms and leveraging nanoformulations are crucial for advancing its clinical application in AS.
  • This review provides insights for future research into natural compounds for cardiovascular disease management.

Keywords:
atherosclerosiscurcumindrug deliveryinflammationnanoformulations

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