Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Screens02:46

Genetic Screens

5.6K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Zebrafish dspb-/- mutant as a model for non-dilated left ventricular cardiomyopathy: exploring cardiac dysfunction and exercise modulation.

Molecular biomedicine·2026
Same author

Computational Discovery and Optimization of a Potent, Selective, and Drug-Like Scaffold for p38α Inhibition.

Drug design, development and therapy·2026
Same author

Discovery of Novel Molecular Scaffolds to Overcome <i>Pseudomonas aeruginosa</i> Aminoglycoside Resistance: Insights for a Consensus Scoring Rational Design Approach.

International journal of molecular sciences·2026
Same author

Enhancing Drug Repurposing with Consensus Docking: Discovery of Novel Discoidin Domain Receptor 1 Inhibitors.

ChemMedChem·2026
Same author

TKI-mediated inhibition of NLRP1 inflammasome restores erythropoiesis in DBA syndrome.

EMBO molecular medicine·2026
Same author

A Promising Anti-dengue Virus Carboxylated-Sesquiterpene Lactone from <i>Stevia entreriensis</i> (Asteraceae).

ACS omega·2025
Same journal

RETRACTED: Sobeh et al. A Polyphenol-Rich Fraction from <i>Eugenia uniflora</i> Exhibits Antioxidant and Hepatoprotective Activities In Vivo. <i>Pharmaceuticals</i> 2020, <i>13</i>, 84.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Correction: Jiménez-Sánchez et al. Antioxidant Enzymes Genetic Variants Associated with Urticaria/Angioedema Induced by Cross-Reactive Hypersensitivity to Nonsteroidal Anti-Inflammatory Drugs. <i>Pharmaceuticals</i> 2026, <i>19</i>, 522.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Correction: Zhao et al. Multifunctional Gel Films of Marine Polysaccharides Cross-Linked with Poly-Metal Ions for Wound Healing. <i>Pharmaceuticals</i> 2022, <i>15</i>, 750.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Intravenous Immunoglobulin Reveals a Novel Protective Mechanism: Targeting the GBP5-Driven Pyroptosis Axis in Experimental Colitis.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

Icariin Attenuates Renal Injury in Streptozotocin-Induced Diabetic Rats with and Without Adenine-Induced Chronic Kidney Disease.

Pharmaceuticals (Basel, Switzerland)·2026
Same journal

AI-Assisted Identification of a Putative Allosteric Ligand Targeting the CDK4/Cyclin D1 Protein-Protein Interface.

Pharmaceuticals (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Jan 10, 2026

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
07:50

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish

Published on: July 16, 2012

14.7K

Synergizing Virtual Screening and Zebrafish Models to Identify Resveratrol-Derived Antiaging Polyphenols.

David Hernández-Silva1,2,3, Cynthia Cabello1,2, María Luisa Cayuela1,2,4

  • 1Grupo de Telomerasa, Cáncer y Envejecimiento, Hospital Clínico Universitario Virgen de la Arrixaca, 30120 Murcia, Spain.

Pharmaceuticals (Basel, Switzerland)
|November 27, 2025
PubMed
Summary
This summary is machine-generated.

Researchers identified potential anti-aging compounds using computer screening and zebrafish. Resveratrol and sakuranetin improved telomere length, while others reduced inflammation, highlighting a combined approach for discovering aging therapies.

Keywords:
agingchronic inflammationpolyphenolsresveratrolshort telomeresvirtual screeningzebrafish

More Related Videos

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
07:45

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

Published on: November 8, 2014

18.2K
Large Scale Zebrafish-Based In vivo Small Molecule Screen
07:03

Large Scale Zebrafish-Based In vivo Small Molecule Screen

Published on: December 30, 2010

14.0K

Related Experiment Videos

Last Updated: Jan 10, 2026

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish
07:50

Facilitating Drug Discovery: An Automated High-content Inflammation Assay in Zebrafish

Published on: July 16, 2012

14.7K
A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos
07:45

A Manual Small Molecule Screen Approaching High-throughput Using Zebrafish Embryos

Published on: November 8, 2014

18.2K
Large Scale Zebrafish-Based In vivo Small Molecule Screen
07:03

Large Scale Zebrafish-Based In vivo Small Molecule Screen

Published on: December 30, 2010

14.0K

Area of Science:

  • Gerontology
  • Pharmacology
  • Computational Biology

Background:

  • Telomere shortening and chronic inflammation are key aging indicators impacting cellular function.
  • Discovering compounds that combat aging is vital for promoting health and longevity.
  • Virtual screening and zebrafish models offer efficient methods for identifying anti-aging agents.

Purpose of the Study:

  • To identify resveratrol-like polyphenols with anti-aging properties using computational methods.
  • To evaluate the efficacy of these compounds in a zebrafish model of aging.

Main Methods:

  • Combined ligand- and structure-based virtual screening of the DrugBank database.
  • Prioritized compounds were tested for anti-aging effects in zebrafish.
  • Utilized pharmacophore similarity and consensus docking for compound selection.

Main Results:

  • Resveratrol and sakuranetin enhanced telomerase-related parameters.
  • Apigenin, genistein, and hesperetin demonstrated significant anti-inflammatory activity.
  • Eight top candidates were identified and validated in vivo.

Conclusions:

  • Integrating in silico and in vivo models accelerates the discovery of aging therapeutics.
  • The dual computational approach provides a reliable pipeline for identifying compounds targeting aging.
  • This study validates the combined strategy for discovering compounds with anti-aging potential.