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Coating Doyle Nasal Silicone Splints with a Sustained Release Varnish Containing Antibiotics Provides Long-Term
Ahmad Siag1,2, Ronit Vogt Sionov1, Irith Gati3
1Institute of Biomedical and Oral Research (IBOR), Faculty of Dental Medicine, The Hebrew University of Jerusalem, Ein Kerem Campus, Jerusalem 9112102, Israel.
Pharmaceuticals (Basel, Switzerland)
|November 27, 2025
Summary
Coating Doyle nasal splints with a sustained-release varnish (SRV) containing antibiotics like chloramphenicol effectively prevents Staphylococcus aureus infections. This novel approach offers long-term antibacterial and antibiofilm protection for nasal implants.
Area of Science:
- Biomaterials Science
- Infectious Disease Research
- Surgical Innovation
Background:
- Doyle nasal silicone splints are crucial in nasal surgeries but are susceptible to bacterial colonization, particularly Staphylococcus aureus.
- This colonization can lead to recurrent and difficult-to-treat sinonasal cavity infections.
Purpose of the Study:
- To develop a sustained-release varnish (SRV) with antibacterial properties for coating Doyle nasal splints.
- To evaluate the long-term antibacterial and antibiofilm efficacy of SRV-coated splints against Staphylococcus aureus.
Main Methods:
- Doyle splint segments were coated with SRV containing augmentin, ciprofloxacin, or chloramphenicol.
- Antibacterial and antibiofilm activities were assessed through bacterial growth monitoring, MTT assays, kinetic disk diffusion, and scanning electron microscopy.
Main Results:
- SRV coatings with augmentin, ciprofloxacin, and chloramphenicol inhibited planktonic growth for 9, 18, and 21 days, respectively.
- Bacterial clearance was achieved for 14, 52, and over 65 days with augmentin, ciprofloxacin, and chloramphenicol, respectively.
- High-resolution scanning electron microscopy confirmed the prevention of biofilm formation.
Conclusions:
- Coating Doyle nasal splints with SRV provides sustained antibacterial and antibiofilm activity.
- SRV containing chloramphenicol demonstrated superior long-term efficacy compared to augmentin and ciprofloxacin.
- Further in vivo studies are warranted to validate this approach for clinical application.
