Organoselenium Compounds Derived from Natural Metabolites
Agata J Pacuła-Miszewska1, Magdalena Obieziurska-Fabisiak2, Jacek Ścianowski2
1Department of Toxicology, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. 107 Hallera Street, 80-416 Gdansk, Poland.
Organoselenium compounds derived from natural metabolites offer diverse applications in organic synthesis and medicinal chemistry. These compounds serve as valuable reagents, catalysts, and building blocks, with potential as antioxidants and GPx-mimetics.
Area of Science:
- Organic Chemistry
- Medicinal Chemistry
- Biochemistry
Background:
- Natural metabolites are abundant, structurally diverse, and enantiomerically pure, making them valuable in synthesis.
- Organoselenium compounds derived from natural scaffolds like amino acids and steroids have been synthesized.
- These compounds find use as reagents, catalysts, building blocks, and potential therapeutics.
Purpose of the Study:
- To review the synthesis and applications of organoselenium compounds derived from natural metabolites.
- To highlight their utility as reagents and catalysts in organic synthesis and biological systems.
- To explore their potential as antioxidants and GPx-mimetics.
Main Methods:
- Literature review focusing on naturally derived organoselenium compounds.
- Categorization into antioxidants/GPx-mimetics and reagents for organic transformations.
- Analysis of synthesis routes and application examples.
Main Results:
- Natural scaffolds facilitate the creation of organoselenium compounds with significant applications.
- These compounds show promise as antioxidant catalysts (GPx-mimetics) in biological systems.
- They are effective reagents in organic transformations, including asymmetric reactions.
Conclusions:
- This review offers a comprehensive overview of organoselenium reagents from natural sources.
- It discusses their advantages in medicinal chemistry and organic synthesis.
- Prospective future research directions are outlined.
More Related Videos
07:30A Direct, Regioselective and Atom-Economical Synthesis of 3-Aroyl-N-hydroxy-5-nitroindoles by Cycloaddition of 4-Nitronitrosobenzene with Alkynones
Published on: January 21, 2020
07:07Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Related Concept Videos
Properties of Organometallic Compounds
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
Preparation and Reactions of Sulfides
Organic Compounds
Structural Isomerism
Isomers are different chemical species that have the same chemical formula. Structural isomerism of coordination compounds can be divided into two subcategories, the linkage isomers and coordination-sphere isomers.
Linkage isomers occur when the coordination compound contains a ligand that can bind to the transition metal center through two different atoms. For example, the CN− ligand can bind through the carbon atom or through the nitrogen atom. Similarly, SCN− can...
Drug Metabolism: Phase II Reactions
