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Related Experiment Video

Updated: Jan 10, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Dietary Bioactive Compounds and Their Role in Allergy Prevention: A Comprehensive Review.

Pilar Zafrilla1, Pura Ballester1, Desirée Victoria-Montesinos1

  • 1Faculty of Pharmacy and Nutrition, UCAM Universidad Católica de Murcia, 30107 Murcia, Spain.

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|November 27, 2025
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Summary

Nutritional compounds like omega-3 fatty acids and vitamin D show promise in allergy prevention and management by modulating immune responses. Further research with standardized formulations is needed to confirm clinical efficacy and safety.

Keywords:
allergic diseasesbioactive compoundscurcuminepigallocatechin gallategingeromega-3 fatty acidsquercetinvitamin D

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Area of Science:

  • Immunology
  • Nutritional Science
  • Allergy Research

Background:

  • Allergic diseases are a global health concern, necessitating novel therapeutic strategies beyond symptom management.
  • Nutritional bioactive compounds are gaining attention for their potential in preventing and modulating immune dysfunction in allergies.

Purpose of the Study:

  • To review the evidence on omega-3 polyunsaturated fatty acids, vitamin D, curcumin, ginger bioactives, quercetin, and epigallocatechin gallate (EGCG) for allergy prevention and management.
  • To summarize preclinical and clinical findings on the immunological and mechanistic effects of these compounds.

Main Methods:

  • A comprehensive literature search was performed across PubMed, Scopus, and Web of Science up to July 2025.
  • Included studies focused on preclinical and clinical outcomes related to allergy, immunology, and mechanisms of action.

Main Results:

  • Omega-3 fatty acids and vitamin D demonstrated immune-modulatory effects with some clinical benefits, though trial results were heterogeneous.
  • Curcumin, ginger bioactives, quercetin, and EGCG showed promising preclinical results in modulating immune pathways and improving allergy symptoms, with varying degrees of clinical evidence and bioavailability challenges.

Conclusions:

  • Preclinical data strongly support the immunomodulatory potential of these nutritional compounds in allergies.
  • Clinical evidence is promising but inconsistent, highlighting the need for standardized formulations, long-term studies, and investigation of synergistic effects for future allergy prevention strategies.