Association Between cMIND Diet and Dementia Among Chinese Older Adults: A Population-Based Cross-Sectional Study

China's rapidly aging population has led to a growing burden of dementia, marked by cognitive decline and heavy social and economic costs. Dietary patterns have been identified as a critical means for prevention.

This study drew on data from the China Longitudinal Health and Longevity Survey (CLHLS). Three logistic regression models were applied to examine the association between the Chinese version of the Mediterranean-Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (cMIND) diet and dementia. To test the stability of the results, we conducted two sensitivity analyses. Restricted cubic spline (RCS) models were used to assess the potential for a nonlinear relationship. Subgroup and interaction analyses were conducted to explore heterogeneity across covariates and main effects. Propensity score matching (PSM) was performed as a secondary analysis to minimize the influence of confounding factors.

The study included 9142 participants, with a dementia prevalence of 10.7% among Chinese older adults. After adjusting for all covariates, each one-unit increase in the cMIND diet score was associated with an 11% lower prevalence of dementia (OR = 0.89; 95% CI: 0.84-0.93). After full adjustment, the RCS model confirmed a significant and linear dose-response association between adherence to the cMIND diet and dementia. Comparable associations were observed across most subgroups.

Adherence to the cMIND diet was significantly associated with a lower prevalence of dementia in Chinese older adults, with evidence of a clear dose-response effect. These findings highlight the potential of the cMIND diet as a preventive strategy against dementia in this population.