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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
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Modulating Strategies of the Intestinal Microbiota in Colorectal Cancer.

María José García Mansilla1, María Jesús Rodríguez Sojo1,2, Andreea Roxana Lista2

  • 1Department of Pharmacology, Centro de Investigación Biomédica (CIBM), University of Granada, 18071 Granada, Spain.

Nutrients
|November 27, 2025
PubMed
Summary

Diet and gut microbiota significantly influence colorectal cancer (CRC) risk. Fiber-rich diets and synbiotics show promise in CRC prevention and as adjunct therapies by modulating the gut microbiota.

Keywords:
colorectal cancermicrobiotapostbioticsprebioticsprobioticstherapeutic approaches

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Area of Science:

  • Gastroenterology and Oncology
  • Microbiology
  • Nutritional Science

Background:

  • Colorectal cancer (CRC) is a major global health concern, with nutrition and gut microbiota emerging as critical factors.
  • Understanding the interplay between diet, gut microbiota, and CRC is crucial for prevention and treatment strategies.

Purpose of the Study:

  • To systematically review the evidence on diet and microbiota-targeted interventions (probiotics, prebiotics, synbiotics, postbiotics) in relation to CRC risk and outcomes.
  • To evaluate the impact of dietary patterns and specific interventions on gut microbiota composition and function in CRC.

Main Methods:

  • A systematic literature search was conducted across major databases (PubMed, Scopus, etc.) up to July 2025.
  • 36 studies were selected based on PRISMA guidelines, analyzing dietary exposures, microbiota modulation, metabolite profiles, and CRC outcomes.
  • Evidence quality was assessed using appropriate appraisal tools for observational and interventional studies.

Main Results:

  • Western diets correlate with gut dysbiosis, pro-inflammatory microbes, and increased CRC risk.
  • Fiber- and polyphenol-rich diets promote beneficial short-chain fatty acid-producing bacteria with anti-cancer effects.
  • Probiotics, prebiotics, and postbiotics show potential in restoring microbial balance and improving treatment tolerance.

Conclusions:

  • A complex relationship exists between nutrition, gut microbiota, and CRC, with significant translational potential.
  • Fiber-rich diets and synbiotics are most promising for CRC prevention and as adjunctive therapies.
  • Further well-designed human clinical trials are needed to validate findings from preclinical models.