Causal relationship between duration of mobile phone use and risk of aneurysmal subarachnoid hemorrhage: A 2-sample...

This study investigates whether the duration of mobile phone use (DMPU) is causally associated with the risk of aneurysmal subarachnoid hemorrhage (aSAH). We pooled data from publicly available genome-wide association studies. DMPU was assessed in European populations (n = 456972), and genome-wide association studies data on patients with aSAH were obtained from the Common Metabolic Disease Knowledge Portal (total n = 337159; cases = 7480; controls = 329679). Inverse-variance weighted was applied as the primary Mendelian randomization (MR) method, and 2-sample MR analyses with sensitivity tests were performed. Twenty-three single nucleotide polymorphisms reaching genome-wide significance were selected as instrumental variables for DMPU. Inverse-variance weighted analysis suggested a causal relationship between excessive DMPU and increased risk of aSAH (odds ratio [OR] = 2.20; 95% confidence interval: 1.26-3.83; P = .006). MR-Egger regression indicated that directional pleiotropy was unlikely to bias the results (OR = 12.93; 95% confidence interval:1.15-145.31; P = .051). The weighted median method supported the causal relationship between excessive DMPU and increased risk of aSAH (OR = 2.48; 95% Cl: 1.17-5.24; P = .018). The Cochrane Q test and funnel plot showed no heterogeneity or asymmetry, confirming the robustness of the findings. This study provides evidence supporting a causal relationship between DMPU and aSAH. Excessive mobile phone use may increase the risk of aSAH, with important implications for clinical practice, public health, and policy.