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Comparison of ciprofol and propofol on dreaming and emotional response during painless gastroscopy: a single-center
Luran Xiong1,2, Kunjie Li1,2, Xinyi Feng1,2
1Department of Anaesthesiology and Operating Theatre Services, Xiangya Hospital of Central South University, Changsha, Hunan, PR China.
Background And Aims:
Ciprofol (HSK3486), a novel intravenous anesthetic with a chemical structure similar to propofol, is not inferior to propofol in terms of its effectiveness. We compared the effects of ciprofol and propofol on dreams and emotional states in patients following painless gastroscopy.
Research Design And Methods:
This was a single-center, randomized controlled trial. The primary outcome was the proportion of positive dreams during sedation.
Results:
A total of 110 outpatients were included, with 55 in each group. The proportion of positive dreams among dreamers was significantly greater in the propofol group than in the ciprofol group (60.9% vs 20.0%; p = 0.020). Additionally, the propofol group exhibited significantly higher positive emotion scores compared to the ciprofol group (19 [15,25] vs 17 [12,21]; p = 0.021). No significant differences were observed in vital signs, BIS values, or satisfaction with the procedure between the two groups. As for the adverse drug reactions, the incidence of injection pain of propofol was significantly higher than that of ciprofol (12.7% vs 0%; p = 0.013).
Conclusions:
Compared to propofol, ciprofol demonstrated a weaker capacity to induce positive dreams and emotions during painless gastroscopy. However, this does not impact patient satisfaction with the procedure.
Clinical Trial Registration:
www.chictr.org.cn; identifier: ChiCTR2400082655.
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