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Updated: Jan 10, 2026

Primary Human Bronchial Epithelial Cells Grown from Explants
Published on: March 26, 2010
Wrong place at the right time, a case of primary bronchial myoepithelial carcinoma
Hermione Jemmett1, Sanjeet Singh Avtaar Singh1,2, Ella Bauwens3
1Department of Cardiothoracic Surgery, Royal Infirmary of Edinburgh, 51 Little France Crescent, Old Dalkeith Road, Edinburgh, EH164SA, United Kingdom.
Abstract:
Primary bronchial myoepithelial carcinoma is a rare neoplasm, accounting for less than 1% of all primary lung malignancies. These tumours typically arise from submucosal tracheobronchial glands and are resistant to chemotherapy and radiotherapy, making surgical resection the preferred treatment. We present the case of a 78-year-old male who was incidentally found to have a right upper lobe endobronchial lesion following investigation for a chest infection. Imaging revealed a 3.8 cm obstructive mass in the right main bronchus. Bronchoscopic biopsy confirmed a high-grade myoepithelial carcinoma. He underwent a serratus-sparing thoracotomy with a bronchial sleeve upper lobectomy and mediastinal lymphadenectomy. The anastomosis was reinforced with a pedicled thymo-pericardial diaphragmatic fat flap. Postoperative recovery was complicated by pneumonia, delirium, and electrolyte imbalance, all of which resolved with appropriate management. Histopathology confirmed complete resection. Follow-up imaging showed no recurrence. This case underscores the importance of early recognition and meticulous surgical management in treating this rare pulmonary malignancy.

