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Related Concept Videos

Magnetic Resonance Imaging01:24

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
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Related Experiment Video

Updated: Jan 10, 2026

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
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Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

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Hyperpolarized MRI theranostics in cancer.

Koya Yamashita1, Zhilei Zhao1, Keita Saito1

  • 1Institute for Quantum Life Science, National Institutes for Quantum Science and Technology (QST), Chiba, Japan.

Frontiers in Oncology
|November 27, 2025
PubMed
Summary

Hyperpolarized MRI uses special probes to visualize cancer metabolism in real-time. This technique, hyperpolarized MRI theranostics, can enhance cancer therapies by targeting metabolic changes.

Keywords:
cancerhyperpolarized MRImetabolismradiotherapytheranostics

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Area of Science:

  • Oncology
  • Medical Imaging
  • Biochemistry

Background:

  • Hyperpolarized magnetic resonance imaging (MRI) offers non-invasive, real-time assessment of tumor metabolism.
  • Molecular probes like [1-13C]pyruvate visualize metabolic changes linked to cancer aggressiveness and treatment response.

Purpose of the Study:

  • To explore the combined use of hyperpolarized magnetic resonance spectroscopic imaging (MRSI) with cancer treatment strategies.
  • To introduce the concept of "hyperpolarized MRI theranostics in cancer" for enhanced DNA-targeted therapies.

Main Methods:

  • Utilizing hyperpolarized molecular probes for in vivo metabolic imaging.
  • Applying insights from metabolic imaging to guide and potentiate cancer therapies, including chemotherapy and radiotherapy.

Main Results:

  • Hyperpolarized MRI can visualize intratumoral metabolic and physiological changes.
  • These visualized changes can be leveraged to enhance the efficacy of subsequent therapeutic interventions.

Conclusions:

  • Hyperpolarized MRI theranostics represent a novel approach to cancer treatment, integrating diagnostics and therapy.
  • Future advancements in hyperpolarized MRI hold significant promise for improving oncological care.